background and objectives: regarding the importance of finding new antibacterial drugs, screening of plants as a promising resource are now conducted worldwide. in this study, we report the application of a simple previously described method for screening of different plant seeds in order to find the best resources of plant antimicrobial peptides. materials and methods: total water soluble prot...

Cell adhesion molecules in Saccharomyces cerevisiae and Candida albicans contain amyloid-forming sequences that are highly conserved. We have now used site-specific mutagenesis and specific peptide perturbants to explore amyloid-dependent activity in the Candida albicans adhesin Als5p. A V326N substitution in the amyloid-forming region conserved secondary structure and ligand binding, but abrog...

Attachment of lytic peptides to the lipid membrane of virions or bacteria is often accompanied by their aggregation and pore formation, resulting eventually in membrane rupture and pathogen neutralization. The membrane rupture may occur gradually via formation of many pores or abruptly after the formation of the first pore. In academic studies, this process is observed during interaction of pep...

Proteolysis of food proteins changes their conformation and often generates bioactive peptides, leading to improved nutritional value techno-functional properties. Protein isolates that originated from plants are generally a mixture several proteins. Enzymatic hydrolysis such mixtures has drawback, as it is unclear which in the hydrolysed, poorly reproducible outcomes. In present study, we appl...

The specificity of peptide activity depends on the sequence amino acids and structure, so it is easy to understand great degree biodiversity that peptides can cover. Accordingly, literature shows carry out various activities, including antiproliferative, antihypertensive, antimicrobial, antioxidant, anticholesterolemic, opioid antidiabetic activities. However, potential strongly quenched by the...

Psoriasis is a chronic inflammatory skin disease with complex pathogenesis involving the interaction between innate and adaptive immune systems. The release of antimicrobial peptides (AMPs) by keratinocytes, particularly LL-37 peptides, plays crucial role in initiation psoriatic inflammation. activation dendritic cells distinct T-cell subsets, Th1 Th17, leads to formation scaly plaques psoriasi...

Since the 1990s, a number of terminal alkynyl residue-containing cyclic/acyclic peptides have been identified from marine organisms, especially cyanobacteria and marine mollusks. This review has presented 66 peptides, which covers over 90% marine peptides with terminal alkynyl fatty acyl units. In fact, more than 90% of these peptides described in the literature are of cyanobacterial origin. In...

Two types of recently described antibacterial peptides derived from human lactoferricin, either nonacylated or N-acylated, were studied for their different interaction with membranes of Escherichia coli in vivo and in model systems. Electron microscopy revealed striking effects on the bacterial membrane as both peptide types induced formation of large membrane blebs. Electron and fluorescence m...