Pseudomonas aeruginosa (PA), which colonizes the airways of approximately 90% of patients with cystic fibrosis (CF) at some point during their lives, is an important contributor to the vicious cycle of infection and inflammation leading to bronchiectasis and eventual respiratory failure. Oral antibiotic therapy is often ineffective in treating PA infections. Instead, in-hospital IV aminoglycosi...

Patented platform technologies have been used for the liposomal encapsulation of cisplatin (Lipoplatin) into tumor-targeted 110 nm (in diameter) nanoparticles. The molecular mechanisms, preclinical and clinical data concerning lipoplatin, are reviewed here. Lipoplatin has been successfully administered in three randomized Phase II and III clinical trials. The clinical data mainly include non-sm...

B iotechnology has created many therapeutic proteins to treat diseases that were incurable 10 years ago (Table 1). Formulating protein delivery systems so that the drugs maintain stability and remain within safe and efficacious target doses remains a challenge. Two general approaches have been used in addressing the delivery of protein therapeutics: • One has focused on noninvasive means of tra...

Given a set of keyphrases, we analyze how Web queries with these phrases can be formed that, taken altogether, return a specified number of hits. The use case of this problem is a plagiarism detection system that searches the Web for potentially plagiarized passages in a given suspicious document. For the query formulation problem we develop a heuristic search strategy based on cooccurrence pro...

2 List of all formulations aranged.In the present study, the design of an oral effervescent tablet of diclofenac potassium was carried out. Six different formulations were prepared using different.The objective of the present study was to formulate aspirin tablets by direct. Method using fewer excipients and to compare this formulation with the other. Study was to formulate Effervescent tablet ...

Effects of formulation parameters on the fractional release profile of diclofenac sodium from matrices having the manufacturing formulation ingredients are studied. As a content of cetyl alcohol (rate controlling agent) in the matrix increases, the fractional release decreases. The fractional release increases either by increasing sucrose content outside the granule or by decreasing sucrose...

In this experiment, the effect of prebiotic Bio-Mos® (MOS) and types of feed formulation (total and digestible amino acids) were evaluated on performance and the small intestine microflora in laying hens for a duration of 10 wks. A total of 168 Hy line W-36 laying hens, with an initial age of 73 wks, were randomly allocated to 4 dietary treatments, 7 replicates and 6 birds in each replicate. Th...