objective(s): mutant forms fms-like tyrosine kinase-3 (flt3), are reported in 25% of childhood acute lymphoid leukemia (all) and 30% of acute myeloid leukemia (aml) patients. in this study, drug response, growth promoting, and protein trafficking of flt3 wild-type was compared with two active mutants (internal tandem duplication (itd)) and d835y. materials and methods:flt3 was expressed on fact...

Using a constrained superposition calculus and a disunification procedure, it is possible to employ superposition-based first-order reasoners for reasoning not only about all models of a first-order theory, but also about all models over a specific finite domain and often as well about the perfect models of the theory (or the unique minimal model in case of a Horn theory), both of which are sec...

Familial dysautonomia (FD) is an autosomal recessive congenital neuropathy which results from poor development and progressive degeneration of the nervous system. The mutation responsible for FD was found at the 5�ss of intron 20 of the IKBKAP gene, encoding the I?B kinase complex-associated protein (IKAP...

We calculate the decay constant of Ds and D ∗ s with B̄ 0 → D+l−ν and B̄0 → D+D s decays. In our analysis we assume the factorization ansatz and use two different form factor behaviours (constant and monopole-type) for F0(q 2). We also consider the QCDpenguin contributions in hadronic decays within the NDR renormalization scheme in a NLO calculation. We estimate the decay constant of the Ds meson...

Familial dysautonomia (FD) is an autosomal recessive congenital neuropathy which results from poor development and progressive degeneration of the nervous system. The mutation responsible for FD was found at the 5�ss of intron 20 of the IKBKAP gene, encoding the I?B kinase complex-associated protein (IKAP...

Familial dysautonomia (FD) is an autosomal recessive congenital neuropathy which results from poor development and progressive degeneration of the nervous system. The mutation responsible for FD was found at the 5�ss of intron 20 of the IKBKAP gene, encoding the I?B kinase complex-associated protein (IKAP...

Familial dysautonomia (FD) is an autosomal recessive congenital neuropathy which results from poor development and progressive degeneration of the nervous system. The mutation responsible for FD was found at the 5�ss of intron 20 of the IKBKAP gene, encoding the I?B kinase complex-associated protein (IKAP...

~Tn'i's project used three methods of DNA identification: (1) DNA typing using single locus probes, (2) DNA fingerprinting with multi-locus probes, and (3) polymerase chain reaction (PCR) for sex determination. The hypothesis to test was whether DNA profiles remain constant over time, including the lifetime of an individual. This has relevance to the potential establishment of computer database...