We show that calmodulin-dependent phosphodiesterase (CAM-PDE) is selectively expressed in mature olfactory receptor neurons within the olfactory mucosa. Immunocytochemical staining reveals neuronal immunoreactivity that is most pronounced within cilia, dendritic knobs, and axon bundles. Neither sustentacular cells nor basal cells display immunoreactivity. The extent of loss of neuronal immunore...

The problem of state-observation is addressed for nonlinear systems that can bemodeled by an ODE–PDE series association. The ODE subsystem assumes a triangular structure while the PDE element is of heat diffusion type. The aim is to accurately estimate online the state vector of the ODE subsystem and the distributed state of the PDE element. One major difficulty is that the state observation mu...

The critical cell density for relaying in D. discoideum, N*, has been measured as a function of cell density, N, and time after harvesting, t. It has logarithmic dependence on N for 2.5 X 10(4)/cm2 less than N less than 7.5 X 10(5)/cm2 and saturates for N more than 1.0 X 10(6)/cm2. N* is an increasing function of time after harvesting. The phosphodiesterase (PDE) secretion rate on which N* depe...

We studied interactions between the mitogen-activated protein kinase (MAPK) signalling pathway and cAMP-protein kinase (PKA) signaling pathway in regulation of mitogenesis of mesangial cells (MC) determined by [3H]thymidine incorporation, with or without added EGF. Forskolin or dibutyryl cAMP strongly (by 60-70%) inhibited [3H]thymidine incorporation into MC. Cilostamide, lixazinone or cilostaz...

We present a PDE-based framework that generalizes Group equivariant Convolutional Neural Networks (G-CNNs). In this framework, network layer is seen as set of PDE-solvers where geometrically meaningful PDE-coefficients become the layer's trainable weights. Formulating our PDEs on homogeneous spaces allows these networks to be designed with built-in symmetries such rotation in addition standard ...

A cDNA clone corresponding to a novel cGMP phosphodiesterase inhibitory subunit (PDE gamma) was isolated from a bovine retinal cDNA library using a rod PDE gamma cDNA as a probe under conditions of reduced stringency. This new clone encodes an 83-amino acid protein approximately 80% identical to rod PDE gamma. The transcript for this protein is retina specific and 940 base pairs in length. Sout...

A Personal Distributed Environment (PDE) is an example of an IP-based system architecture designed for future mobile communications. In a single PDE, there exist several Subnetworks hosting devices located across the infrastructure, which will inter-work with one another through the coordination of a Device Management Entity (DME). Some of these Sub-networks are fixed and some are mobile. In or...

This paper deals with the construction and characterization of discrete PDE splines. For this purpose, we need a PDE equation (usually an elliptic PDE), certain boundary conditions and a set of points to approximate. We give two results about the convergence of a discrete PDE spline to a function of a fixed space in two different cases: (1) when the approximation points are fixed; (2) when the ...

We investigated the kinetics and sensitivity of photocurrent responses of salamander rods, both in darkness and during adaptation to steady backgrounds producing 20-3,000 photoisomerizations per second, using suction pipet recordings. The most intense backgrounds suppressed 80% of the circulating dark current and decreased the flash sensitivity approximately 30-fold. To investigate the underlyi...

‎It is commonly accepted that fractional differential equations play‎ ‎an important role in the explanation of many physical phenomena‎. ‎For‎ ‎this reason we need a reliable and efficient technique for the‎ ‎solution of fractional differential equations‎. ‎This paper deals with‎ ‎the numerical solution of a class of fractional differential‎ ‎equation‎. ‎The fractional derivatives are described...