Most long-bone fractures heal through indirect or secondary fracture healing, a complex process in which endochondral ossification is an essential part and bone is regenerated by tissue differentiation. This process is sensitive to the mechanical environment, and several authors have proposed mechano-regulation algorithms to describe it using strain, pore pressure and/or interstitial fluid velo...

BACKGROUND AND OBJECTIVES Studies have shown decreased bone mineral density in individuals with urolithiasis, but their burden of fracture remains unclear. This study sought to determine whether urolithiasis is associated with increased fracture risk across the lifespan and to delineate sex effects. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS A population-based retrospective cohort study us...

STUDY DESIGN Retrospective case series of one institute database. OBJECTIVE To investigate the differences in the metallic strength of rods used for implant failure in the dual growing rod technique and evaluate clinical outcomes. SUMMARY OF BACKGROUND DATA The dual growing rod technique in which implanted rods extend with the growth of the spine is a useful treatment for early onset scolio...

BACKGROUND Currently it is uncertain how to define osteoporosis and who to treat after a hip fracture. There is little to support the universal treatment of all such patients but how to select those most in need of treatment is not clear. In this study we have compared cortical and trabecular bone status between patients with spinal fractures and those with hip fracture with or without spinal f...

This study introduces a novel methodology for the design of the proppant pumping schedule for a hydraulic fracture, in which the final proppant distribution along the crack is prescribed. While the design is based on the assumption that the particles have relatively weak impact on the fracture propagation, the validity of this assumption can be tested a posteriori. This makes it possible to rel...

Background: Thrombin related peptide (TP508) is a 23 amino-acid synthetic peptide that represents a portion of the receptor-binding domain of thrombin molecule. Previous studies have shown that TP508 can accelerate musculoskeletal tissue repair including fracture healing. Objectives: The aim of this study was to investigate the effect of TP508 on fracture healing in a murine fracture model repr...