Elevated intraocular pressure (IOP) is one of the major risk factors for glaucomatous visual field defects. Each individual systemic risk factor of coronary heart disease (CHD) is associated with elevated IOP, although no reports have argued for a correlation between the risk factors for CHD and IOP after a comprehensive or collective analysis. The National Cholesterol Education Program Adult T...

BACKGROUND Gender differences in prevalence and consequences of the metabolic syndrome as a strong predictor of cardiovascular disease (CVD), are challenging problems. Postmenopausal status may explain in part the cause of acceleration of CVD with aging. The purpose of this study was to investigate the relation of menopause and metabolic syndrome independent of aging among Iranian women. METH...

BACKGROUND AND PURPOSE The purpose of this study was to investigate whether the Framingham Cardiovascular Risk Profile and carotid artery intima-media thickness are associated with cortical volume and thickness. METHODS Consecutive subjects participating in a prospective cohort study of aging and mild cognitive impairment enriched for vascular risk factors for atherosclerosis underwent struct...

In their thoughtful and provocative article ‘Are the Framingham and PROCAM coronary heart disease risk functions applicable to different European populations? The PRIME Study’, Drs Empana and colleagues astutely conclude that the answer is neither simple nor straightforward. On the one hand, they conclude that the Framingham (from the United States) and PROCAM (from Germany) risk functions over...

BACKGROUND AND PURPOSE We wished to test the validity of a stroke probability point system from the Framingham Study for a sample of the population of Copenhagen, Denmark. In the Framingham cohort, the regression model of Cox established the effect on stroke of the following factors: age, systolic blood pressure, the use of antihypertensive therapy, diabetes mellitus, cigarette smoking, prior c...

The prevalence of ischemic heart disease and atherosclerosis is increased in patients with rheumatoid arthritis (RA). In the general population, but not in patients with systemic lupus erythematosus, the Framingham risk score identifies patients at increased cardiovascular risk and helps determine the need for preventive interventions. We examined the hypothesis that the Framingham score is inc...

INTRODUCTION AND OBJECTIVES The Framingham coronary heart disease (CHD) functions overestimate the risk of CHD in countries with a low incidence. Consequently, these functions should be calibrated for the purpose of primary prevention. Calibrated Framingham function charts of overall CHD risk for the Spanish population are presented. Patients and methods. The Framingham functions were calibrate...

STUDY OBJECTIVES To evaluate the performance of the Framingham, national health epidemiologic follow up study, and the WHO ERICA risk scores in predicting death from coronary heart disease (CHD) in an Australian population. DESIGN Cohort follow up study. SETTING AND PARTICIPANTS The cohort consisted of 1923 men and 1968 women who participated in health surveys in the town of Busselton in We...

BACKGROUND Risk prediction in elderly patients is increasingly relevant due to longer life expectancy. OBJECTIVES This study sought to examine whether electrocardiographic (ECG) changes provide prognostic information incremental to current risk models and to the conventional risk factors. METHODS In all, 6,991 participants from the Copenhagen Heart Study attending an examination at age ≥65 ...