The pharmacology and regulation of corticosteroid binding globulins (CBG) in Dark-eyed Juncos, Junco hyemalis, was investigated. The equilibrium dissociation constant for [(3)H]corticosterone (CORT) binding to plasma was <5 nM. This binding site had a similar high affinity for progesterone, approximately fivefold lower affinity for androgens, and negligible affinity for estradiol. The following...

The androgen status of 25 male patients with rheumatoid arthritis (RA) was assessed and compared with that of age matched controls with osteoarthritis (OA). Significantly reduced levels of serum free testosterone were found in the RA group. Within that group free testosterone was unrelated to all indices of disease activity measured, though it was strongly related to latex positivity. These res...

Free testosterone was measured in the saliva of 89 male prison inmates. Inmates with higher testosterone concentrations had more often been convicted of violent crimes. The relationship was most striking at the extremes of the testosterone distribution, where 9 out of 11 inmates with the lowest testosterone concentrations had committed nonviolent crimes, and 10 out of 11 inmates with the highes...

The investigation of clinical and physiological problems related to androgen production has been hampered by lack of an adequate measure of testosterone production. As one approach to this problem, Finkelstein, Forchielli, and Dorfman (1) developed a sensitive method for the measurement of free testosterone in plasma. The subsequent identification of testosterone in the urine (2) as the glucuro...

Objective: Pumpkin (Cucurbita pepo L.) seed oil mainly consists of saturated and unsaturated fatty acids. Previously, it was reported that oral administration of pumpkin seed oil (PSO) improved hair growth in male pattern alopecia. This study aimed to evalua...

BACKGROUND Current methods of testosterone replacement therapy are limited to fixed-dosage patches and depot injections. Neither of these methods provides ideal therapy because of the inflexibility of dosing and other nuisance problems associated with the patches and nonphysiologic hormone levels when depot injections are used. Testosterone gels offer the potential for convenience and ease of a...