AP1 (jun/fos) transcription factors (c-jun, junB, junD, c-fos, FosB, Fra-1, and Fra-2) are key regulators of epidermal keratinocyte survival and differentiation and important drivers of cancer development. Understanding the role of these factors in epidermis is complicated by the fact that each protein is expressed, at different levels, in multiple cells layers in differentiating epidermis, and...

PURPOSE This study aims to identify differentially expressed genes in esophageal squamous cell carcinoma (ESCC) through the use of a membrane-based cDNA array. EXPERIMENTAL DESIGN Two newly established human ESCC cell lines (HKESC-1 and HKESC-2) and one corresponding to a morphologically normal, esophageal epithelium tissue specimen, prospectively collected from the HKESC-2-related patient, w...

Pedicle screws (PS) can provide initial stabilization of anterior interbody femoral ring allograft (FRA) lumbar constructs. Translaminar screws (TLS) have also been advocated for this procedure. The objective of this study was to use an in vitro human cadaveric model to compare the stability of one-level anterior interbody lumbar constructs stabilized with PS and those stabilized with TLS. Five...

Studies using genetically modified mice have revealed fundamental functions of the transcription factor Fos/AP-1 in bone biology, inflammation, and cancer. However, the biological role of the Fos-related protein Fra-2 is not well defined in vivo. Here we report an unexpected profibrogenic function of Fra-2 in transgenic mice, in which ectopic expression of Fra-2 in various organs resulted in ge...

Methotrexate (MTX) is still the gold standard for treatment of rheumatoid arthritis (RA). The therapeutic efficacy of low-dose of MTX can be increased by its combination with a natural substance, ferulaldehyde (FRA). The aim of this study was to evaluate the effect FRA and MTX administered alone or in combination in adjuvant arthritis. The disease was induced to Lewis male rats by intradermal i...

This paper presents a non-orthogonal multiple access (NOMA) concept for future radio access (FRA) towards the 2020s information society. Different from the current LTE radio access scheme (until Release 11), NOMA superposes multiple users in the power domain although its basic signal waveform could be based on the orthogonal frequency division multiple access (OFDMA) or the discrete Fourier tra...

Ambiguity in terms of property rights, displacement and livelihood insecurity, among others has been causes of distress among tribal communities, resulting in tribal unrest, social tensions and conflicts in Kerala and other parts of India. In response, forest policies were implemented with the most recent being the Scheduled Tribes and Other Traditional Forest Dwellers Recognition of Forest Rig...

This paper proposed an efficient and adaptive frequency sampling algorithm for response analysis using dynamic condensation-based reduced-order modeling. For the degree of freedom-based model reduction method, basis becomes a frequency-dependent matrix since relationship between master slave degrees freedom stems from partial equations second-order dynamical system. Such frequency-dependency ma...