Background: Recently, in patients with normal tension glaucoma (NTG) elevated levels of antiphosphatidylserine antibodies (APSA), a subgroup of antiphospholipid antibodies (APLA) were found. Progressive sensorineural hearing loss (PSHL) is associated with autoimmune diseases and also the presence of APLA. Methods: To investigate a possible association between NTG and PSHL, 34 patients (age rang...

PURPOSE Candida albicans subretinal abscess is extremely rare. To our knowledge, only one unilateral case has been reported. Herein, we report one bilateral case. Mixed bacterial infection was also suspected based on broad-range real-time polymerase chain reaction. METHODS A 64-year-old man being treated with oral corticosteroids for interstitial pneumonia visited us for visual loss in the le...

A 52-year-old man with no previous medical history, but a high body mass index (BMI) >34, presented with a sudden onset of a painful, apparently proptosed left eye and decreased left vision (see figure 1). He had rubbed his eye on waking. On examination, there was no relative afferent pupillary defect. Snellen chart testing was 6/12 (pinhole 6/6) ocular sinistra (OS) and 6/6 ocular dextra (OD)....

PURPOSE To describe the clinical findings of a patient with an early onset retinal dystrophy and a novel mutation in OTX2, and to compare these findings with previously reported cases. METHODS Using direct sequencing, we screened 142 patients, who had either Leber congenital amaurosis (LCA) or early onset retinal dystrophy (EORD), for mutations in OTX2. All patients received a detailed ophtha...

PURPOSE To describe the first instance of genotyping in a Latin American family with Wolfram syndrome (WS). METHODS Four affected siblings and their healthy parents were studied. Ophthalmologic examination included best corrected visual acuity determination, funduscopy, fluorescein retinal angiography, and Goldmann kinetic perimetry. Molecular methods included linkage analysis using microsate...

BACKGROUND We attempted to review the clinical and fundus findings in patients with malignant hypertension (MHT). METHODS Charts and fundus photographs of patients with malignant hypertensive retinopathy from 1995 to 2000 were retrospectively reviewed. Data of patients were included when their color fundus photographs revealed findings suggestive of malignant hypertension (MHT). There had to ...

PURPOSE To assess the impact of intrastromal corneal ring segments (ICRS) as a surgical alternative to corneal grafting in patients with keratoconus who were scheduled for a corneal transplant. METHODS This single-surgeon, single-center, retrospective, observational case series study included 19 eyes of 18 patients (mean age, 23.36 ± 6.22 years) with a confirmed diagnosis of keratoconus. Thes...

A 53-year-old man presented with a 5-month history of visual loss in his left eye. Visual acuity could be corrected to 20/20 with an increased hyperopic correction. Dilated funduscopy showed faint choroidal folds and elevation of the left optic disc. The coronal view of T2-weighted magnetic resonance imaging demonstrated a fluid-filled dilated sheath surrounding normal optic nerves. General phy...

RATIONALE, AIMS AND OBJECTIVES Continuous quality improvement programmes often target several aspects of care, some of which may be more effective meaning that resources could be focussed on these. The objective was to identify the effective and ineffective aspects of a successful continuous quality improvement programme for individuals with type 2 diabetes in primary care. METHODS Data were ...

This article reports a case of possible involvement of membrane tissue on the optic disc with macular schisis formation associated with glaucomatous optic disc without optic disc pits. A 78-year-old man presented with loss of central visual acuity of the left eye. He had a medical history of primary open-angle glaucoma. Visual acuity was 0.6 in his left eye, and funduscopy revealed macular schi...