10.2217/14750708.4.2.125 © 2 Invasive fungal infections continue to be associated with high rates of morbidity and mortality, primarily in the immunocompromised hosts. Candida and Aspergillus are the most common causes of invasive fungal disease; however, other fungi can also cause disease in humans. Current therapeutic options for the management of invasive fungal infections include the polyen...

Fungal exopolysaccharides (EPSs) represent an important group of bioactive compounds secreted by fungi. These biopolymers can be utilized individually or in combination with different substances for a broad range pharmaceutical field applications, due to their various biological activities, such as antioxidant, antimicrobial, anti-inflammatory, antiviral, anti-diabetic, and anticoagulant effect...

The study of fungal physiology is set to change dramatically in the next few years as highly scalable technologies are deployed allowing accurate measurement and identification of metabolites, proteins and transcripts within cells. The advent of next-generation DNA-sequencing technologies will also provide genome sequence information from large numbers of industrially relevant and pathogenic fu...

The antimicrobial activity of some novel ascorbic acid-metal complexes [bisascorbate complexes of copper (II), zinc(II), manganese (11), iron (111), cobalt(II), lead(II) and cadmium(II)] was investigated. Four standard strains of bacterial species - Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Klebsiella pneumonia and four fungal species - Trichophyton sp. Penicillium sp....

Compounds obtained from marine organisms have been isolated due to their anti-bacterial and antifungal activities. In this study, the antifungal activity of aqueous-methanol, methanol, chloroform and n-hexane extracts of body wall, guts and white strings of sea cucumber (Holothuria leucospilota) collected from Chabahar Bay in 100 to 2000 μg/ml concentrations is discussed. The antifunga...

Objective: The genus Trichoderma comprises a great number of fungal strains that act as biological control agents, the antagonistic properties of which are based on the activation of multiple mechanisms. Methods: Trichoderma strains exert biocontrol against fungal phytopathogens either indirectly, by competing for nutrients and space, modifying the environmental conditions, or promotin...

The high capacity of the secretion machinery of filamentous fungi has been widely exploited for the production of homologous and heterologous proteins; however, our knowledge of the fungal secretion pathway is still at an early stage. Most of the knowledge comes from models developed in yeast and higher eukaryotes, which have served as reference for the studies on fungal species. In this review...

Out of 12 fungal strains, two fungal strains, namely Aspergillus flavus AT-2 and Aspergillus niger AT-3, were found to produce maximum cellulase production. The CMCase activities of A. flavus AT-2 and A. niger AT-3 under state solid fermentation (SSF) conditions were of 42.69 and 40.08%, respectively, which was higher than those obtained under submerged fermentation (SmF) conditions. A fungal i...

Adaptation to different types of environmental stress is a common part of life for today's fungi. A deeper understanding of the organization, regulation and evolution of fungal stress response systems may lead to the development of novel antifungal drugs and technologies or the engineering of industrial strains with elevated stress tolerance. Here we present the Fungal Stress Response Database ...

A survey of the fungi isolated from the digestive tract of Panstrongylus megistus (insects vectors from Chagas' disease) used on xenodiagnosis was carried out. Two hundred and fourteen fungal strains were isolated from 180 nymphs. Aspergillus and Penicillium were the most predominant genera and some of their species were new records concerning insects. A great reduction in the fungal population...