Footrot is a common inflammatory bacterial disease affecting the health and welfare of sheep worldwide. The pathogenesis of footrot is complex and multifactorial. The primary causal pathogen is the anaerobic bacterium Dichelobacter nodosus, with Fusobacterium necrophorum also shown to play a key role in disease. Since immune-mediated pathology is implicated, the aim of this research was to inve...

Lemierre's syndrome is a rare but indefinitely severe illness caused by the anaerobic bacterium, Fusobacterium necrophorum. It typically occurs in healthy teenagers and young adults who usually start as a throat infection which spreads via a septic thrombophlebitis of the tonsillar vein and internal jugular vein. Furthermore, the spread of infection is complicated by septic emboli to other site...

Lemierre's syndrome is caused by acute oropharyngeal infection with septic secondary thrombophlebitis of the internal jugular vein and metastatic infection. Fusobacterium necrophorum is the most commonly implicated aetiological agent. The authors present the case of a healthy young man presenting with a history of general malaise and sore throat who developed septic metastatic complications in ...

bitis can progress very rapidly— often in a matter of hours—and even with appropriate surgical and antibiotic treatment, it can be fatal or result in serious complications. Escardo et al reported a case of orbital cellulitis caused by F necrophorum that required 3 urgent surgical interventions and 30 days of intravenous antibiotic treatment. Despite this intensive treatment, the patient’s visio...

Biapenem is a carbapenem being developed in combination with RPX7009, a new inhibitor of serine β-lactamases. Biapenem was tested alone and in combination with fixed concentrations of RPX7009 by agar dilution against 377 recent isolates of anaerobes. A separate panel of 27 isolates of Bacteroides spp. with decreased susceptibility or resistance to imipenem was also tested. Comparator drugs incl...

The bile tests for characterizing gram-negative anaerobic bacilli were reevaluated in prereduced anaerobically sterilized peptone-yeast-glucose broth, in thioglycollate broth, and on blood agar plates. Blood agar plates were unsatisfactory. The combination of 20% bile with 0.1% desoxycholate inhibited Fusobacterium, Bacteroides melaninogenicus, and B. oralis and sometimes Sphaerophorus necropho...