The thromboembolic phenomenon is nowadays considered to be a multicausal disease, in which the fact of being the carrier of a congenital prothrombotic disorder is not the cause, but rather an additional risk factor in the onset of thrombosis occurring as the result of the sum of various risk factors. These factors are usually a combination of external circumstances (precipitating factors) and a...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. There have been growing concerns about venous throm-boembolism (VTE), especially in Western counties where the incidence is greater than Asian counties. showing significantly lower incidence of VTE in children and adolescents in comparison to adults [1]. Alt...

Why does post-transplant osteonecrosis develop? Sir, We read with interest the article by Ekmekci et al. [1], on the association of thrombophilia and osteonecrosis (ON) of the femoral head in renal transplant recipients. We previously reported a case with diffuse ON and severe osteoporosis which was unusual in its presentation in the early post-transplant period, focusing on pre-transplant horm...

Q. What conditions comprise ocular thrombosis? CJG Ocular thrombosis includes central and branch retinal vein occlusion (CRVO), central retinal artery occlusion (CRAO), amaurosis fugax (AF), and non-­arteritic ischemic optic neuropathy (NAION), all of which are closely related to coagulation abnormalities. In the United States, branch and central retinal rein occlusions are the second most comm...

BACKGROUND Thromboembolic disease (TED) represents one of the main reasons of morbitity and mortality in Western World. Venous and arterial thrombotic disorders have long been viewed as separate pathophysiological entities. However, in recent times the separate nature of arterial and venous thrombotic events has been challenged. Although inherited thrombophilia's predominant clinical manifestat...

CONTEXT The link between long-haul air travel and venous thromboembolism is the subject of continuing debate. It remains unclear whether the reduced cabin pressure and oxygen tension in the airplane cabin create an increased risk compared with seated immobility at ground level. OBJECTIVE To determine whether hypobaric hypoxia, which may be encountered during air travel, activates hemostasis. ...

Thromb Haemost 2008; 99: 651–652 Anticoagulants represent a mainstay in the current management of arterial thromboembolism. Heparins are recommended for virtually all forms of acute coronary syndromes (1, 2), whereas long-term oral anticoagulation is of proven benefit in the treatment of patients with atrial fibrillation at high risk of stroke, prosthetic mechanical heart valves, chronic heart ...

Background—The aim of this study was to estimate the impact of thrombophilia on risk of first childhood stroke through a meta-analysis of published observational studies. Methods and Results—A systematic search of electronic databases (Medline via PubMed, EMBASE, OVID, Web of Science, The Cochrane Library) for studies published from 1970 to 2009 was conducted. Data on year of publication, study...

To the Editor: Genetic tests for risk factors for venous thromboembolism (1 ) are increasingly available. We report the results of a survey that included a search for 3 thrombophilia mutations. The survey was organized by the Subcommittee on Hemostasis of the CISMEL (Italian Committee for Standardization of Laboratory Tests). The scheme enrolls 250 participants, of which 52 are also registered ...