BACKGROUND To examine the association of glucose-6-phosphate dehydrogenase (G6PD) deficiency with adolescent physical and mental health, as effects of G6PD deficiency on health are rarely reported. METHODS In a population-representative Chinese birth cohort: "Children of 1997" (n = 8,327), we estimated the adjusted associations of G6PD deficiency with growth using generalized estimating equat...

Due to contaminated food sources from China, hepatitis E virus (HEV) has become the leading cause of acute oral-faecal transmitted hepatitis in Hong Kong. Notification of incidence is required by law. From 2001 to 2010, a total of 525 cases were reported to the Department of Health. Of these, 352 were men and 173 were women, with a male to female ratio of 2:1. The median age of the patients was...

Tumor lysis syndrome (TLS) is a life-threating hematologic emergency caused by massive lysis of tumor cells into the blood stream. TLS can be prevented and treated with rasburicase. Rasburicase-induced hemolysis and methemoglobinemia is a rare but serious complication. Screening for G6PD should be considered for patients at higher risk for G6PD deficiency who may be also at high risk for TLS on...

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an enzymopathy in which reduced NADPH concentrations are not maintained, resulting in oxidative damage. We evaluated G6PD activity, oxidative stress levels and Trolox equivalent antioxidant capacity in individuals with the A-(202G>A) mutation for G6PD deficiency. Five hundred and forty-four peripheral blood samples were screened for G6PD de...

A survey of a number of ethnic groups in the Mediterranean region, Middle East and Africa has demonstrated that the pattern of distribution of G6PD deficiency roughly corresponds to that of sickle cell trait, thalassemia and malarial infection (10). Gilles et al. (2) reported G6PD deficiency in Negro leprosy patients in Africa. Gilles and Taylor (3) observed that 2% of Negro leprosy patients ha...

In southern China, glucose-6-phosphate dehydrogenase (G6PD) deficiency is a significant health problem, and the incidence ranged from 0.5 to 4.08% in different Chinese population. The aims of this study are to investigate the molecular epidemiological characteristic of the G6PD gene among Chinese Hakka in southern Jiangxi province. 2331 unrelated subjects were screened for G6PD deficiency by a ...

Objective Glucose 6-phosphate dehydrogenase (G6PD) deficiency increases the risk of neonatal hyperbilirubinemia. The aim this study is to evaluate factors associated with hyperbilirubinemia in infants from western part Guangdong Province, and assess contribution G6PD jaundice. Methods term People's Hospital Yangjiang June 2018 July 2022 were recruited for retrospective analysis. All underwent q...

Glucose-6-PHOSPHATE dehydrogenase (G6PD; EC 1.1.1.49) deficiency is the most common human enzymopathy, affecting more than 200 million people worldwide. Although greater than 400 variants have been described based on clinical and biochemical criteria, little is known about the molecular basis of these G6PD deficiencies. Recently, the gene that encodes human G6PD has been cloned and sequenced, w...

The X-chromosome-linked glucose-6-phosphate dehydrogenase (D-glucose-6-phosphate:NADP+ oxidoreductase, EC 1.1.1.49) of humans and other mammals consists of a subunit with a molecular weight of about 58,000. The enzyme plays a key role in the generation of NADPH, particularly in matured erythrocytes, and the genetic deficiency of the enzyme is associated with chronic and drug- or food-induced he...