The globus pallidus (GP) contains abundant GABAergic synapses and GABA(B) receptors. To investigate whether synaptically released GABA can activate pre- and postsynaptic GABA(B) receptors in the GP, physiological recordings were performed using rat brain slice preparations. Cell-attached recordings from GABA(A) antagonist-treated preparations revealed that repetitive local stimulation induced a...

The single channel properties of recombinant gamma-aminobutyric acid type A (GABA(A))alphabetagamma receptors co-expressed with the trafficking protein GABARAP were investigated using membrane patches in the outside-out patch clamp configuration from transiently transfected L929 cells. In control cells expressing alphabetagamma receptors alone, GABA activated single channels whose main conducta...

In neuronal cells the intracellular trafficking machinery controls the availability of neurotransmitter receptors at the plasma membrane, which is a critical determinant of synaptic strength. Metabotropic γ amino-butyric acid (GABA) type B receptors (GABA(B)Rs) are neurotransmitter receptors that modulate synaptic transmission by mediating the slow and prolonged responses to GABA. GABA(B)Rs are...

Bennett, Ben D., John R. Huguenard, and David A. Prince. blockade of GABA uptake (Isaacson et al. 1993; Thompson Adrenoceptor-mediated elevation of ambient GABA levels actiand Gähwiler 1992), application of convulsant drugs (Otis vates presynaptic GABAB receptors in rat sensorimotor cortex. J. and Mody 1992; Scanziani et al. 1991), or electrical stimulaNeurophysiol. 78: 561–566, 1997. At inhibi...

gamma-Aminobutyric acid type A (GABA(A)) receptors, a family of Cl(-)-permeable ion channels, mediate fast synaptic inhibition as postsynaptically enriched receptors for gamma-aminobutyric acid at GABAergic synapses. Here we describe an alternative type of inhibition mediated by GABA(A) receptors present on neocortical glutamatergic nerve terminals and examine the underlying signaling mechanism...

Brain-derived neurotrophic factor (BDNF) modulates several distinct aspects of synaptic transmission, including GABAergic transmission. Exposure to BDNF alters properties of GABA(A) receptors and induces changes in the expression level at the cell surface. Although phospholipase C-related inactive protein-1 (PRIP-1) plays an important role in GABA(A) receptor trafficking and function, its role ...

The chemistry of the gamma aminobutyric acid (GABA) had been established. However, the explanation on the interplay between GABA receptors antagonize fundamental concept of the GABAergic Signaling‎. For example, glutamate spillover from excitatory afferent terminals leads to the modulation of GABAergic signals. However, this result is true with respect to GABAB receptors only. The physics of it...

γ-Aminobutyric acid (GABA) is the most prominent neuroinhibitory transmitter in the brain, where it activates neuronal GABA-A receptors (GABA-A channels) located at synapses and outside of synapses. The GABA-A receptors are primary targets of many clinically useful drugs. In recent years, GABA has been shown to act as an immunomodulatory molecule. We have examined in human, mouse and rat CD4(+)...

Aim We examined if tonic ?-aminobutyric acid (GABA)-activated currents in primary hippocampal neurons were modulated by insulin wild-type and tg-APPSwe mice, an Alzheimer's disease (AD) model. Methods GABA-activated recorded dentate gyrus (DG) granule cells CA3 pyramidal brain slices, from 8 to 10 weeks old (young) mice dorsal DG adult, 5-6 10-12 (aged) months the absence or presence of insulin...

Repeated cocaine causes enduring changes in dopamine and glutamate transmission in the nucleus accumbens, and dopamine and glutamate terminals synapse on GABAergic accumbens neurons. The present study demonstrates that there are changes in GABA transmission in the accumbens at 3 weeks after discontinuing daily cocaine injections. No-net flux microdialysis revealed a significant increase in the ...