Glucocorticoids (GCs) immunosuppression acts via regulation of several transcription factors (TF), including activating protein (AP)-1, NF-kappaB, and NFAT. GCs inhibit Th1 cytokines and promote a shift toward Th2 differentiation. Th1 phenotype depends on TF T-bet. In this study, we examined GC regulation of T-bet. We found that GCs inhibit T-bet transcriptional activity. We show that glucocort...

Tungsten trioxide (WO₃) nanorods are synthesized on the surface of graphene (GR) sheets by using a one-step in-situ hydrothermal method employing sodium tungstate (Na₂WO₄·2H₂O) and graphene oxide (GO) as precursors. The resulting WO₃/GR nanocomposites are characterized by X-ray diffraction, Raman spectroscopy, transmission electron microscopy, scanning electron microscopy and X-ray photoelectro...

After the successful solvothermal synthesis of graphene (GR) from ethanol and sodium, we obtained chemically bonded graphene/BiOCl (GR/BiOCl) nanocomposite photocatalysts via a facile chemical-bath method. A significant enhancement was observed in the photodegradation of methylbenzene, which was largely ascribed to the chemical coupling effects between Bi and C, as shown by X-ray photoelectron ...

The physics potential of the next generation of Gamma Ray Telescopes in exploring the Gamma Ray Horizon is discussed. It is shown that the reduction in the Gamma Ray detection threshold might open the window to use precise determinations of the Gamma Ray Horizon as a function of the redshift to either put strong constraints on the Extragalactic Background Light modeling or to obtain relevant in...

The Large Area Telescope (LAT) on board the Gamma-ray Large-Area Space Telescope (GLAST) is a pair-conversion gamma-ray detector designed to explore the gamma-ray universe in the 20 MeV– 300 GeV energy band. The Tracker subsystem of the LAT will perform tracking of electron and positrons to determine the origin of the gamma-ray. The design and performance of the GLAST LAT Tracker are described ...

AGILE is a small space mission of the Italian Space Agency (ASI) devoted to gamma-ray and hard-X astrophysics, successfully launched on April 23 2007. The AGILE Payload is composed of three instruments: a gamma-ray imager based on a tungsten-silicon tracker (ST), for observations in the gamma ray energy range 30 MeV 50 GeV, a Silicon based X-ray detector, SuperAGILE (SA), for imaging in the ran...

The Geminga pulsar has long been one of the most intriguing MeV-GeV gamma-ray point sources. We examine the implications of the recent Milagro gamma-ray Observatory detection of extended, multi-TeV gamma-ray emission from Geminga, finding that this reveals the existence of an ancient, powerful cosmic-ray accelerator that can plausibly account for the multi-GeV positron excess that has evaded ex...

Mycosis fungoides (MF) is a cutaneous T-cell lymphoma characterized by multifocal disease and protracted clinical course. The few studies that have assessed T-cell receptor (TCR) gene rearrangements (GRs) present at different anatomic sites in MF have generally reported a common clone. We used a previously validated 4-color polymerase chain reaction (PCR) assay to assess the size and V-family u...

The polarization of relativistic jets is of interest for the understanding of their origin, confinement, and propagation. However, even though numerous measurements have been performed, the mechanisms behind jet variability, creation, and composition are still debated. We have performed simultaneous gamma-ray and optical photopolarimetry observations of 45 blazars with the Kanata telescope sinc...

The GALPROP model for cosmic-ray propagation is able to make explicit predictions for the distribution of galactic diffuse gamma-rays. We compare different propagation models with gamma-ray spectra measured by EGRET for various regions of the sky. This allows sensitive tests of alternative explanations for the apparent excess emission observed at GeV gamma-rays. We find that a population of har...