Objective(s): Gastroesophageal Reflux Disease (GERD) is one of the most common digestive disorders that frequently lead to pulmonary complications due to gastric fluid aspiration. In the present experimental study, chronic aspiration of gastric fluid, its components and bile salts in rat lung was performed to find out the main factor(s) causing pulmonary complications of gastric fluid aspirat...

The successful therapy strategy of gastric cancer is defined as devastating of the cancerous cells without exposing systematic toxicity and undesirable side effects. One strategy to overcome cancer treatment related difficulties could be combination therapy with natural products with anticancer drugs to introduce effective antitumor effects in addition to reduction of undesirable side effects. ...

Background: North of Iran is amongst high incidence rate areas of gastric carcinoma where environmental carcinogenic compounds especially agricultural pesticides are massively used. Cytochrome P450 2E1 (CYP2E1) enzyme metabolically activates a large number of low molecular mass xenobiotics. The polymorphic nature of cyp2E1 gene control elements is associated with interindividual differences...

We studied the relationship between gastroduodenal inflammation and the presence of Campylobaeter pylori from biopsy specimens of the gastric mucosa in 91 patients with gastritis with or without ulcers and 9 controls, healthy or suffering from other diseases. 68 of the patients were positive for the presence of C. pylori in their gastric mucosa. C. pylori was confirmed bacteriohistological...

background : gastric cancer as the fourth most frequent malignancy worldwide was known to have the highest rate among cancer-related disorders in ardabil province. the product of tp53 gene regulated  the cell cycle process and acts as a tumor suppressor factor. the polymorphism p53 arg72pro (rs1042522) has been reported to be associated with many type of cancers.  the purpose of the present stu...

objective(s): prostaglandins have been shown to mediate the gastro-protective effect of sodium hydrosulfide (nahs) but effect of nahs on mrna expression of prostaglandin e2 receptors (ep1, 3-4; eps) has not been investigated. therefore, this study designed to evaluate the effect of nahs on mrna expression of eps receptors in response to mucosal acidification and distention-induced gastric acid ...

background and objective: host genetic factors such as cytokine gene polymorphisms as well as helicobacter pylori (h. pylori) infection have been found to be associated with gastric cancer risk . interleukin 1 is a pro-inflammatory cytokine involved in h. pylori-induced gastric inflammation. therefore, we analyzed the association between il-1β and il-1-rn polymorphisms and gastric cancer in per...

introduction: gastric cancer is the second most common gi malignancy in zahedan. this investigation was undertaken to define the demographic,clinicopathological, and prognostic factors relevant to patients withgastric adenocarcinoma. methods: we did a retrospective study of 100 patientswith gastric cancer who had been at ali ebne abitaleb hospital and khatam al anbia hospitalin 2004-2006. data ...

metformin has recently been introduced as an anti-cancer agent. in this study, we evaluated the effect of metformin and metformin/cisplatin on human gastric mkn-45 cell line. when we used metformin alone, it could inhibit proliferation and induce apoptosis, but it diminish anti-proliferative effects of cisplatin when they are used in combination. further, we checked mrna levels of survivin, mto...