OBJECTIVE Long non-coding RNAs (lncRNAs), emerging non-coding RNAs, have been proved to serve as a critical role in the proliferation, metastasis apoptosis of gastric cancer. However, the potential biological role PCAT-1 in gastric cancer (GC) remains undefined. The present study aimed to investigate the expression and clinical significance of PCAT-1 in GC. PATIENTS AND METHODS The expression...

AIM OF THE STUDY To assess influencing factors and main health-related quality of life (HRQoL) issues in patients with cancers of the oesophago-gastric region using the European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire Core 30 (QLQ-C30) and its oesophago-gastric module (QLQ-OG25). MATERIAL AND METHODS Patients were qualified for this study based ...

Malignancies associated with the upper gastrointestinal (GI) tract are reported to be ex‐ tremely lethal. Most patients with gastric cancer (GC) in the United States are symptomatic and already have complex untreatable disease at the time of presentation. GC in general, is a senile malignancy (cancer of the aged) and is reportedly twice as common in blacks as in whites. Routine screening is not...

Cyclin-dependent kinase (CDK) family members have been considered as attractive therapeutic targets for cancer. In this study, we aim to investigate the anticancer effects of a selective CDK7 inhibitor, BS-181, in gastric cancer (GC) cell line. Human GC cells (BGC823) were cultured with or without BS-181 at different concentrations for 24-72 hours. BS-181 significantly reduced the activity of C...

UNLABELLED The aim of this study was to detect the hypoxic status in adjacent histologically uninvolved gastric mucosa in gastric cancer (GC) patients. PATIENTS AND METHODS 50 naïve patients with primary GC, and one patient with stomach ulcer (gastric mucosa was used as control) were enrolled into the study. The tumor and mucosa samples of stomach (without muscularis and serosa layers) in pat...

Cluster of differentiation 90 (CD90) (Thy-1) plays important roles in the oncogenesis in various types of malignancies. In the present study, we investigated the expression of CD90 in gastric cancer (GC) tissues by q-PCR, immunohistochemistry (IHC), and western blot technologies. The results showed that CD90 was overexpressed in gastric cancer tissues compared with the level in the adjacent non...

background : gastric cancer is a common and lethal disease throughout the world. in iran with 7300 new cases annually, it is the first cause of cancer related death in both sexes. regarding the high incidence (10.5/100000 individuals) of gastric can­cer and priority of prevalence index in cancer management, in this study we tried to determine 1, 2-3 and 4-5 year point preva­lence of the disease...

Esophageal and gastric cancer (GC) are related to obesity and bariatric surgery. Risk factors, such as gastroesophageal reflux and Helicobacter pylori, must be investigated and treated in obese population. After surgery, GC reports are anecdotal and treatment is not standardized. This review aims to discuss GC related to obesity before and after bariatric surgery.

Background and Aim: Gastric cancer (GC) is one of the most common infection-related malignancies worldwide. Human Papillomavirus (HPV) Epstein-Barr virus (EBV) are among important viruses affecting many people The potential role these in gastric tissue may explain possibility GC, as seen Helicobacter pylori (H. pylori). This study aimed to systematically investigate presence HPV EBV GC. Methods...

BACKGROUND AND AIM The human CD24 antigen is a small heavily glycosylated cell surface protein, which is expressed in a large variety of solid tumors,including gastric cancer. Enriched on the surface of many tumor cells,CD24 promotes tumor growth,invasion and metastasis and confers resistance to some chemotherapeutic drugs.In this study, we investigated the possible effect of CD24 suppression o...