Janowski E, Berríos M, Cleemann L, Morad M. Developmental aspects of cardiac Ca signaling: interplay between RyRand IP3R-gated Ca stores. Am J Physiol Heart Circ Physiol 298: H1939–H1950, 2010. First published March 19, 2010; doi:10.1152/ajpheart.00607.2009.—The dominant mode of intracellular Ca release in adult mammalian heart is gated by ryanodine receptors (RyRs), but it is less clear whethe...

OBJECTIVES The purpose of this study was to evaluate the accuracy of electrocardiogram (ECG)-gated single-photon emission computed tomography (SPECT) for assessment of left ventricular (LV) end-diastolic volume (EDV), end-systolic volume (ESV) and ejection fraction (EF) compared with the gold standard of cardiac magnetic resonance imaging (MRI). BACKGROUND Several comparisons of ECG-gated SPECT...

PURPOSE Ventricular function is a powerful predictor of survival in patients with heart failure (HF). However, studies characterizing gated F-18 FDG PET for the assessment of the cardiac function are rare. The aim of this study was to prospectively compare gated F-18 FDG PET and cardiac MRI for the assessment of ventricular volume and ejection fraction (EF) in patients with HF. METHODS Eighty...

OBJECTIVE We wanted to evaluate the performance of prospective electrocardiogram (ECG)-gated axial scans for assessing coronary stents as compared with retrospective ECG-gated helical scans. MATERIALS AND METHODS As for a vascular model of the coronary artery, a tube of approximately 2.5-mm inner diameter was adopted and as for stents, three (Bx-Velocity, Express2, and Micro Driver) different...

The accurate delivery of respiratory-gated volumetric modulated arc therapy (VMAT) treatment plans presents a challenge since the gantry rotation and collimator leaves must be repeatedly stopped and set into motion during each breathing cycle. In this study, we present the commissioning process for an Anzai gating system (AZ-733VI) on an Elekta Versa HD linear accelerator and make recommendatio...

Convolutional and bidirectional recurrent neural networks have achieved considerable performance gains as acoustic models in automatic speech recognition in recent years. Latest architectures unify long short-term memory, gated recurrent unit and convolutional neural networks by stacking these different neural network types on each other, and providing short and long-term features to different ...

Voltage-gated sodium channels expressed on the plasma membrane activate rapidly in response to changes in membrane potential in cells with excitable membranes such as muscle and neurons. Macrophages also require rapid signaling mechanisms as the first line of defense against invasion by microorganisms. In this study, our goal was to examine the role of intracellular voltage-gated sodium channel...

Excitability is an attribute of life, and is a driving force in the descent of complexity. Cellular electrical activity as realized by membrane proteins that act as either channels or transporters is the basis of excitability. Electrical signaling is mediated by a wave of action potentials, which consist of synchronous redistribution of ionic gradients down ion channels. Ion channels select for...

The SMO model for analyzing the temporal behavior of general synchronous systems has proven to be very effective. This paper extends the model to systems in which the clock signals can be gated (conditional). We describe a method for verifying the timing of such systems. Our approach hinges on the use of information about design intent in the analysis to obtain good accuracy. Ingredients for a ...