PURPOSE Multidrug resistance is one of the main impediments to the successful treatment of colon cancer. Glucosylceramide synthase (GCS) which is related to multidrug resistance (MDR) can reduce the level of ceramide and can help cells escape from the ceramide-induced cell apoptosis. However, the underlying mechanism is still unclear. METHODS The cell proliferation and cell toxicity were meas...

Glucocorticoids (GCs) are potent anti-inflammatory and immunosuppressive agents. They act by two different mechanisms: the genomic and the non-genomic pathways. The genomic pathway is considered responsible for many adverse effects of GCs, most of them are time and dose dependent. Observational studies support a relationship between GCs and damage in SLE. GCs have been associated with the devel...

GCS: group C Streptococcus URI: upper respiratory tract infection S treptococcus dysgalactiae, a group C Streptococcus (GCS), is a Gram-positive bacterium that is a commensal colonizer of the upper respiratory tract and skin. Initially thought to be nonpathogenic, increasing evidence suggests it is an important bacterial pathogen in humans. It has been implicated in a variety of infections incl...

BACKGROUND Pyloric cells with "glassy" cytoplasm were detected 20 years ago in the human gastric mucosa, and subsequently in the gastric mucosa of two baboons and of transgenic mice. These pyloric cells, called glassy cells (GCs) show a homogeneous, eosinophilic material that pushes the nucleous towards the free border of the cell. MATERIALS AND METHODS The frequency of baboons having pyloric...

Group C Streptococcus (GCS) is a rare cause of bacteremia in humans. It is mostly associated with zoonological infections. Although GCS can be part of the normal oral, skin, and genitourinary fora, an infection with this pathogen can be highly virulent, causing rapid, disseminating disease. With a mortality of about 25%, the poor prognosis is linked to the severity of illness and the high level...

We consider the model checking problem for Gap-order Constraint Systems (GCS) w.r.t. the branching-time temporal logic CTL, and in particular its fragments EG and EF. GCS are nondeterministic infinitely branching processes described by evolutions of integer-valued variables, subject to Presburger constraints of the form x−y ≥ k, where x and y are variables or constants and k ∈ N is a non-negati...

We consider the model checking problem for Gap-order Constraint Systems (GCS) w.r.t. the branching-time temporal logic CTL, and in particular its fragments EG and EF. GCS are nondeterministic infinitely branching processes described by evolutions of integer-valued variables, subject to Presburger constraints of the form x− y ≥ k, where x and y are variables or constants and k ∈ N is a non-negat...

The Generalized Cornu Spiral (GCS) was first proposed by Ali et al. in 1995 [1, 9]. Due to the monotonocity of its curvature function, the surface generated with GCS segments has been considered as a high quality surface and it has potential applications in surface design [12]. In this paper, the analysis of GCS segment is carried out by determining its aesthetic value using the log curvature G...