We report on the results of a prospective treatment of 30 proven metastatic pancreatic cancer patients with the recently described combination of gemcitabine and erlotinib (GEM+E) (24× 1st line therapy, 8× 2nd line therapy). Eight of these patients received GEM+E for treatment of metastastic tumour recurrence after previous resective surgery, followed by adjuvant chemotherapy with gemcitabine. ...

Performance of the triple-GEM detector with optimized 2-D readout in high intensity hadron beam. Abstract Multiple-GEM detectors are considered to be good candidates for tracking devices in experiments with high hadronic background. We present the results of the triple-GEM detectors beam test in a high intensity pion beam. The detectors had an optimized two-dimensional readout with minimized st...

OBJECTIVE To describe application of GEM to analysis and categorization of guideline content. METHOD We examined the application of GEM constructs to the AAP guideline on neurodiagnostic evaluation of febrile seizures. Subjects at 4 sites marked-up the guideline content using a hierarchical template that includes branches for identity, developer, purpose, intended audience, method of developm...

Petroleum reservoir engineering requires solutions to the transient diffusion and convection-diffusion equations. Traditionally these calculations are carried out using finite difference methods. Prior workers have used perturbation-based boundary element methods for single phase flow in heterogeneous media. The current work applies the Dual Reciprocity Boundary Element Method (DRBEM) and the G...

The Conference on Guideline Standardization (COGS) was convened to create a standardized documentation checklist for clinical practice guidelines in an effort to promote guideline quality and facilitate implementation. The statement was created by a multidisciplinary panel using a rigorous consensus development methodology. The Guideline Elements Model (GEM) provides a standardized approach to ...

The aim of this work is to develop an XML-based application for the automated generation of decision rules from a textual guideline encoded using the Guideline Elements Model (GEM). A formalization of guideline-based chronological steps of treatment has been proposed to resolve the semantic ambiguities of the original document. The GEM DTD has been extended in order to standardize both decision...

In this study we explored how parental exposure to pharmaceuticals influences reproduction in offspring. Adult zebrafish (Danio rerio) were exposed for 6 weeks to 10 μgL(-1) of carbamazepine (CBZ) and gemfibrozil (GEM), two commonly prescribed drugs. Embryos were collected, reared in clean water until sexual maturity and then assessed for reproductive output, courtship, sperm function and organ...

PURPOSE The purpose of this trial was to evaluate the role of radiation therapy with concurrent gemcitabine (GEM) compared with GEM alone in patients with localized unresectable pancreatic cancer. PATIENTS AND METHODS Patients with localized unresectable adenocarcinoma of the pancreas were randomly assigned to receive GEM alone (at 1,000 mg/m(2)/wk for weeks 1 to 6, followed by 1 week rest, t...

Conventional chemotherapy of pancreatic cancer (PaCa) suffers the problems of low drug permeability and inherent or acquired drug resistance. Development of new strategies for enhanced therapy still remains a great challenge. Herein, we report a new ultrasound-targeted microbubble destruction (UTMD)-promoted delivery system based on dendrimer-entrapped gold nanoparticles (Au DENPs) for co-deliv...