Highlight ResearchThe leopard coral grouper Plectropomus leopardus was identified and analysed based on molecular approach.Genetic diversity within two regions in Gorontalo, Sulawesi successfully performed using connectivity analysis.Three haplotypes of from region Gorontalo as one economical important marine fish species. AbstractBar-cheek trout (P. leopardus) is the flagship live market Asia....

To investigate the utility of Y chromosome microsatellites for studying human male-lineage evolution, we typed samples from three populations for five tetranucleotide repeats and an Alu insertion polymorphism. We found very high levels of haplotype diversity and evidence that most mutations involve the gain or loss of only one repeat unit, implying that any given microsatellite haplotype may ha...

The growth hormone receptor (GHR) is potentially involved in prostate cancer through its role in stimulating insulin-like growth factor I production and its cellular effects on prostate epithelium. We have used a haplotype-based tagging approach within CAncer Prostate Sweden, a large retrospective case-control study of 2,863 cases and 1,737 controls to investigate if genetic variation in the GH...

BACKGROUND A previous genome-wide linkage study of alcohol dependence in multiplex families found a suggestive linkage result for a region on Chromosome 1 near microsatellite markers D1S196 and D1S2878. The KIAA0040 gene has been mapped to this region (1q24 - q25). A recent genome-wide association study using SAGE (the Study of Addiction: Genetics and Environment) and COGA (Collaborative Study ...

The yellow fever mosquito Aedes aegypti was introduced in Peru in 1852 and was considered to be eradicated in 1958. In 2001, Ae. aegypti had been recorded in 15 out of 24 Peruvian Departments. Peru has great ecological differences between the east and west sides of Andes. Because of this, we consider that Ae. aegypti populations of both east and west sides can have a genetically distinct popula...

Relevance – it is promising to develop a system for the diagnosis and prevention of primary open-angle glaucoma (POAG), which would be based on determination constitutive propensity factors able predict onset progression disease. The aim study was model predicting rate depending gender endothelial NO-synthase (NOS3) gene polymorphism. There were genotyped 153 patients with POAG aged 36-84 years...

The DMA (DM ? chain) gene, a member of non-classical MHC class II plays an important role in the process presenting antigen peptides by producing DM protein. This study aimed to identify polymorphism gene and their associations with disease resistance traits such as total IgY concentration ND antibody titers IPB-D2 chicken line. sample used was 101 chickens consisted 81 G0 (53 female 28 male) 2...

MOTIVATION Most genome-wide association studies rely on single nucleotide polymorphism (SNP) analyses to identify causal loci. The increased stringency required for genome-wide analyses (with per-SNP significance threshold typically approximately 10(-7)) means that many real signals will be missed. Thus it is still highly relevant to develop methods with improved power at low type I error. Hapl...

We applied a gene-based haplotype approach for the genome-wide association analysis on hypertension using Genetic Analysis Workshop 18 data for unrelated individuals. Association of single-nucleotide polymorphisms and clinical outcome were first assessed and haplotypes were then constructed based on the gene information and the linkage disequilibrium plot. Extensive haplotype analysis was also ...