نتایج جستجو برای: gene expression il 1b
تعداد نتایج: 1705519 فیلتر نتایج به سال:
Abstract Augmenting and sustaining a durable immunity provided by COVID-19 mRNA vaccines is important. Thus, we characterized S protein-specific CD4 +T cells in healthy individuals who received utilizing single cell RNA-seq mass cytometry. In humans, highly expressed IL-1 receptor (R) 1 its decoy IL-1R2. IL-1b promoted IFN-g expression protein-stimulated cells, which was furthered adding anti-I...
Hidradenitis suppurativa (HS) is a chronic debilitating inflammatory disease characterized by complex lesion morphology including nodules, abscesses, and epithelialized sinus tracts. The heterogeneity of HS histopathology has not been fully elucidated represents challenge in comprehensive molecular analyses. Current studies have categorized transcriptomes lesional perilesional tissue, but none ...
IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, but etiology and pathogenesis continue to be poorly understood. Polymorphisms in the cytokine genes may play a role in the etiology and pathogenesis of IgAN. The incidence of different between diverse ethnic groups suggested important genetic influences on its pathogenesis.We genotype 10 single nucleotide po...
BACKGROUND In vitro study has shown that mechanisms for inhibiting interferon (IFN)-α antiviral action by non-structural 5A protein include interaction with IFN-induced RNA-dependent protein kinase and induction of interleukin (IL)-8 expression. Mutations in the non-structural 5A IFN sensitivity-determining region (ISDR) were reported to correlate with sustained virological response (SVR). IL-8...
In the early 1980s, by determination of Boorola gene (FecB) in Booroola sheep with high ovulation rate, there has been a great interest for identification genes that are responsible prolificacy and their use breeding programs. The mutation occurred Bone morphogenetic protein 15 (BMP15), protein-1B (BMPR-1B) Growth differentiation factor 9 (GDF9) have found to increase rate. Additionally some ot...
Abstract Human immunodeficiency virus (HIV) initiates a perpetual cycle of inflammation in the brain that results neuronal damage and consequent neurologic dysfunction. Since HIV preferentially infects damages specific regions, there is need for study antiviral immune markers region manner. We have evaluated expression (IFNa, IFNb, TRAIL, MX1) (CCL2, IL-6, IL-1b, IL-10) across nine regions our ...
Interleukin (IL) 1-ra is a potent endogenous competitive inhibitor of IL-α and β and has an anti-inflammatory role. Study objectives were: 1) to assess the associations of IL-1RN genetic single nucleotide polymorphism (SNP) (rs419598) with generalized chronic periodontitis (GCP), generalized aggressive periodontitis (GAgP), and absence of periodontitis and 2) to assess its association with the ...
Backgrounds and objectives: Interleukin 2 (IL-2) secreted by activated CD4+ T cells has been known as a major mediator in both adaptive and native immune system due to a board range of effects on different cells in the immunity system (1-6). Methods: cDNA synthesis was performed using gene- specific primers designed by Gene Runner software after RNA extraction of mouse splenocytes. PCR pro...
Objective(s): Interleukin-12 (IL-12) as a cytokine has been proved to have a critical role in stimulating the immune system and has been used as immunotherapeutic agents in cancer gene therapy. Chitosan as a polymer, with high ability of binding to nucleic acids is a good candidate for gene delivery since it is biodegradable, biocompatible and non-allergenic polysaccharide. The objective of the...
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