PURPOSE This study evaluates the prognostic performance of a 15 gene expression profiling (GEP) assay that assigns primary posterior uveal melanomas to prognostic subgroups: class 1 (low metastatic risk) and class 2 (high metastatic risk). DESIGN Prospective, multicenter study. PARTICIPANTS A total of 459 patients with posterior uveal melanoma were enrolled from 12 independent centers. TE...

Optimally hybrid numerical solvers were constructed for massively parallel generalized eigenvalue problem (GEP). The strong scaling benchmark was carried out on the K computer and other supercomputers for electronic structure calculation problems in the matrix sizes of M = 104 − 106 with upto 105 cores. The procedure of GEP is decomposed into the two subprocedures of the reducer to the standard...

Is the risk of metastasis equivalent between a class 2 tumor (GEP) and monosomy 3 tumor as determined by MLPA? The concordance between these tests in patients with uveal melanoma undergoing a prognostic fine-needle aspiration biopsy (FNAB) has not been studied until recently. In a retrospective study, GEP and FISH (44 patients) or GEP and MLPA (49 patients – 6 technical failures GEP [3] and MLP...

The PnET-Day model was independently parameterized to compare with estimated eddy covariance gross ecosystem production (GEP; gC m 2 day ) in a mature mixed hardwood and a mature red pine (Pinus resinosa) forest in Northern Wisconsin during the growing season of 2002 and 2003. The mature hardwood forest was dominated by Populus tremuloides, Populus grandidentata, Betula papyrifera, Quercus rubr...

BACKGROUND A single non-invasive gene expression profiling (GEP) test (AlloMap®) is often used to discriminate if a heart transplant recipient is at a low risk of acute cellular rejection at time of testing. In a randomized trial, use of the test (a GEP score from 0-40) has been shown to be non-inferior to a routine endomyocardial biopsy for surveillance after heart transplantation in selected ...

PURPOSE Aurora kinases play a crucial role in cell-cycle control. Uncontrolled expression of aurora kinases causes aneuploidy and tumor growth. As conservative treatment options for advanced gastroenteropancreatic neuroendocrine tumors (GEP-NET) are disappointing, aurora kinases may be an interesting target for novel therapeutic strategies. EXPERIMENTAL DESIGN Human GEP-NETs were tested for a...

With everyday lives becoming increasingly energy intensive, the need of the hour is to plan for the growing demand for clean energy in the future. This research project anticipates a very high wind penetration future for Iowa, and with it the necessity to upgrade or build transmission to transfer the energy to load centers in the east and south. Unlike the traditional planning approach which id...

Positive pathogens prediction is the basis of pathogenic spectrum analysis, which is a meaningful work in public health. Gene Expression Programming (GEP) can develop the model without predetermined assumptions, so applying GEP to positive pathogens prediction is desirable. However, traditional time-adjacent sliding window may not be suitable for GEP evolving accurate prediction model. The main...

In recent years, incremental rate of electrical demands made many challenges for policy makers of power systems. Besides, due to economic crisis and environmental concerns about the air pollution, the new investments in thermal power generation units have experienced a noticeable reduction. For this reason, the power system operators should propose novel approaches to make a balance between inc...

Impairment of natural killer (NK) cell activity is an important mechanism of tumor immunoevasion. We have previously shown that expression of granulin-epithelin precursor (GEP) in hepatocellular carcinoma (HCC) cells rendered the cells resistant to NK cell immunosurveillance. Here, we examined whether targeting GEP could rescue NK activity in HCC patients. The current study demonstrated that qu...