The successful completion of the Human Genome Project led to the discovery of the molecular basis of thousands of genetic disorders. The identification of the mutations that cause familial dysautonomia (FD), an autosomal recessive disorder that impacts sensory and autonomic neurons, was aided by the release of the human DNA sequence. The identification and characterization of the genetic cause ...

We characterized a multidrug-resistant (MDR) Enterobacter spp. isolate highlighting the genetic aspects of antimicrobial resistance genes. An (Ec61) was recovered in 2014 from transtracheal aspirate sample patient admitted to Brazilian tertiary hospital and submitted further microbiological genomic characterization.

Cell-free environments are becoming viable alternatives for implementing biological networks in synthetic biology. The reconstituted cell-free expression system (PURE) allows characterization of genetic networks under defined conditions but its applicability to native bacterial promoters and endogenous genetic networks is limited due to the poor transcription rate of Escherichia coli RNA polyme...

The accuracy of animal breeding value estimation is important for achieving the maximum genetic progress various economically traits in populations. study conducted a comparative characterization repeatability and intercorrelation across estimates obtained using different approaches to incorporating genomic information.

The type b capsule of pathogenic Haemophilus influenzae is a critical factor for H. influenzae survival in the blood and the establishment of invasive infections. Other pathogenic factors associated with type b strains may also play a role in invasion and sustained bacteremia, leading to the seeding of deep tissues. The gene encoding haemocin is the only noncapsular gene found to be specific to...

A central problem in the theory of genetic algorithms is the characterization of problems that are difficult for GAs to optimize. Many attempts to characterize such problems focus on the notion of Deception, defined in terms of the static average fitness of competing schemas. This article examines the Static Building Block Hypothesis (SBBH), the underlying assumption used to define Deception. E...

avian infectious bronchitis is an acute and highly contagious disease that mainly causes respiratory symptoms in poultry. a number of serotypes and variants of the viral agent with poor cross-protection are the major problem to achieve desired immunity from vaccination. the s1 subunit of s glycoprotein (spike) is the major determinant of ibv so that a minor change in amino acid sequence of this...

The completion of many malaria parasite genomes provides great opportunities for genomewide characterization of gene expression and high-throughput genotyping. Substantial progress in malaria genomics and genotyping has been made recently, particularly the development of various microarray platforms for large-scale characterization of the Plasmodium falciparum genome. Microarray has been used f...

introduction: while little is known about the molecular mechanisms that establish the apical growth patterns in fungal mycelia, recent research on the genetics of a. nidulans and n. crassa has provided considerable amount information on some genes involving in polarised cell growth. a.nidulans is particularly amenable to experimental analysis and is importantly related to other human pathogen f...

two peroxidases (ec. 1.11.1.7), pod i and pod ii were purified from the roots of cultivatedraphanus sativus l. var. cicil by one step ion-exchange chromatography after fractionation by acetone. the molecular weight of these enzymes were 43000 and 41000 daltons and rz 1.2 and 2.0 for pod i and pod ii, respectively. both enzymes consisted of a single polypeptide chain on sds-page. the maximum act...