The problem of teacher placement in a school is faced by Magelang Regency. success determined the minimum total distance between and school, with aim that performance maintained. In computer science this an NP-hard takes very long time to achieve optimal results when done conventional methods. Another approach solve use heuristic algorithms, one which using genetic algorithms. To further improv...

Heart disease is a leading cause of death worldwide, and the need for effective predictive systems major source to treat affected patients. This study aimed determine how improve accuracy Random Forest in predicting classifying heart disease. The experiments performed this were designed select most optimal parameters using an RF optimization technique GA. Genetic Algorithm (GA) used optimize pr...

background: pharmacogenomics is the study of genetic variations among individuals to predict the probability that a patient will respond to single or multidrug chemotherapy. breast cancer is one of the most common cancers among women worldwide. treatment of breast cancer by application of biological rationales gives us the ability to match the correct pharmacology to individual tumour genetic p...

Background: Acceleration of adaptation dynamics by stress-induced hypermutation has been found experimentally. Evolved evolvability is a prominent explanation. We investigate a more generally applicable explanation by a physical constraint. Methods and Results: A generic thermodynamical analysis of genetic information storage obviates physical constraints on the integrity of genetic information...

the witkop syndrome is a rare autosomal dominant disorder characterized by the absence of several teeth and abnormalities of the nails. this is the first report of a rare genetic tooth and nail syndrome diagnosed in a 2.5-year-old boy with early exfoliation of the primary canine, absence of the primary incisors, and nail dysplasia. a homozygous mutation was identified in 3’-utr of msx1 gene in ...

introduction: congenital long qt syndrome (lqts) is a cardiac disorder characterized by qt interval prolongation at basal ecg. different lqts genes encode ion channel subunits or proteins involved in regulating cardiac ionic currents. long qt syndrome type 6 (lqt6) is caused by mutation in the kcne2 gene. our research aimed to analyze genetic variants of kcne2 gene causing the disease in irania...

Genetic alteration is the driving force for thyroid tumorigenesis and progression, based upon which novel approaches to the management of thyroid cancer can be developed. A recent important genetic finding in thyroid cancer is the oncogenic T1799A transversion mutation of BRAF (the gene for the B-type Raf kinase, BRAF). Since the initial report of this mutation in thyroid cancer 2 years ago, ra...

Genetic variation is needed for developing new superior varieties in plant breeding. of chili plants could be increased by inducing mutation with gamma rays irradiation. The aim this study was to determine radiosensitivity two local pepper calculating the lethal dose values at LD20 and LD50. Chili (Capsicum frutescens L.) seeds origin from Tulungagung Ponorogo were irradiated cobalt-60 doses of...