Neurodegenerative diseases (NDDs) are associated with genetic variations including point substitutions, copy number alterations, insertions and deletions. At present, a few genetic variation repositories for some individual NDDs have been created, however, these databases are needed to be integrated and expanded to all the NDDs for systems biological investigation. We here build a relational da...

Three clinical strains of enterohemorrhagic Escherichia coli O157:H7 which were subcultured repeatedly or stored at room temperature over a 25-week period showed appreciable variations in their pulsed-field gel electrophoresis fragment patterns. The variations could be explained by a couple of spontaneous genetic events at most and thus did not invalidate the genetic lineage of the strains.

Among the factors postulated to play a role in MS susceptibility, the role of vitamin D is outstanding. Since the function of vitamin D receptor (VDR) represents the effect of vitamin D on the body and genetic variations in VDR gene may affect its function, we aim to highlight the association of two VDR gene polymorphisms with MS susceptibility. In current study, we recruited 113 MS patients an...

malaysian mahseer, tor douronensis, locally known as “kelah” in peninsular malaysia or semah in sarawak is one of the important mahseers used for food as well as the aquarium industry and game fishing. this species is endemic to malaysian borneo river basins. the wild stocks of t. douronensis have declined substantially in recent years, due to over exploitation, pollution and illegal fishing pr...

research results and facts of indigenous sheep production were reviewed with the aim of delivering relevant information for the beneficiaries. the common production system used in ethiopia was the extensive type, which was characterized by small flock sizes and the flock being periodically devastated by diseases. some indigenous sheep groups of the country were characterized and their names wer...

this study is focused on developing an integrated optimization-simulation based genetic algorithm model (iosga) to develop the operational policies for a multi-purpose reservoir system. the objective function of the optimization model is considered to be a linear function of reliability (rel), resiliency (res), and vulnerability (vul) of the river-reservoir system. genetic algorithm (ga) is emp...

Iran is a part of the secondary centre of origin of melons, and therefore, there is a wealth of genetic variation of these species in this country. The Amplified Fragment Length Polymorphism (AFLP) marker was applied to investigate the genetic variations among five major Iranian melon cultigens (Cucumis melo) and ‘Ananasi’ as a general well-known cultivar. Ten primer pairs were used on 90 indiv...

Purpose: Several causes for primary ovarian insufficiency have been described, including iatrogenic and environmental factor, viral infections, chronic disease as well as genetic alterations. Given the large number of genes described in the literature so far, the aim of this review was to collect all the genetic mutations associated with non-syndromic primary ovarian insufficiency. Methods: All...