نتایج جستجو برای: genome wide association study
تعداد نتایج: 4629884 فیلتر نتایج به سال:
The absence of horns, known as the polled phenotype, is an economically important trait in modern yak husbandry, but the genomic structure and genetic basis of this phenotype have yet to be discovered. Here, we conducted a genome-wide association study with a panel of 10 horned and 10 polled yaks using whole genome sequencing. We mapped the POLLED locus to a 200-kb interval, which comprises thr...
We used a case–control genome-wide association (GWA) design with cases consisting of 1238 individuals from the top 0.0003 (~170 mean IQ) of the population distribution of intelligence and 8172 unselected population-based controls. The single-nucleotide polymorphism heritability for the extreme IQ trait was 0.33 (0.02), which is the highest so far for a cognitive phenotype, and significant genom...
The cost of whole genome sequencing is dropping rapidly. There has been a great deal of enthusiasm about the potential for this technological advance to transform clinical care. Given the interest and significant investment in genomics, this seems an ideal time to consider what the evidence tells us about potential benefits and harms, particularly in the context of health care policy. The scale...
Index 4 powerGWASinteraction Power calculations for identifying interactions in GWAS studies Description This function carries out approximate power calculations for identifying SNP x SNP and SNP x environment interactions in genome-wide association (GWAS) studies. It assumes a two-stage analysis , where only SNPs that are significant at a marginal significance level alpha1 are investgigated fo...
There are no easy answers in complex disease genetics. Common, chronic health conditions such as obesity and heart disease are influenced by many genetic variants scattered across the genome, with each variant making small contributions to risk. Ever-larger genome-wide association studies (GWAS) are uncovering more and more of these variants. For many diseases and disease-related traits, discov...
Study Hypothesis Initial genome-wide association studies (GWAS) for hypertension, a common cardiovascular risk factor, have delivered unexpectedly few and modest associations. The authors of the International Consortium for Blood Pressure Genome-Wide Association Studies set out to identify novel genetic variants in relation to blood pressure, intermediate phenotypes, and cardiovascular disease ...
Large-scale Genome-Wide Association Studies (GWAS) for complex diseases are increasingly common, due to recent advances in genotyping technology. Gene-gene interactions play an important role in the etiology of complex diseases and have to be addressed in GWAS. In this paper, an efficient strategy based on two-stage analysis is proposed. It combines a single-locus approach with a Goodness-Of-Fi...
Assortative mating on educational attainment leads to genetic spousal resemblance for causal alleles
Article history: Received 7 June 2016 Received in revised form 25 July 2016 Accepted 14 August 2016 Available online xxxx We examinedwhether assortative mating for educational attainment (“likemarries like”) can be detected in the genomes of ~1600 UK spouse pairs of European descent. Assortative mating on heritable traits like educational attainment increases the genetic variance and heritabili...
In response to the growing interest in genome-wide association study (GWAS) data privacy, the Integrating Data for Analysis, Anonymization and SHaring (iDASH) center organized the iDASH Healthcare Privacy Protection Challenge, with the aim of investigating the effectiveness of applying privacy-preserving methodologies to human genetic data. This paper is based on a submission to the iDASH Healt...
An increasing number of genome-wide association (GWA) studies are now using the higher resolution 1000 Genomes Project reference panel (1000G) for imputation, with the expectation that 1000G imputation will lead to the discovery of additional associated loci when compared to HapMap imputation. In order to assess the improvement of 1000G over HapMap imputation in identifying associated loci, we ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید