DNA methylation is related closely to sequence contexts and chromatin modifications; however, their potential differences in different genomic regions across cell types remain largely unexplored. We used publicly available genome-scale DNA methylation and histone modification profiles to study their relationships among different genomic regions in human embryonic stem cells (H1), H1-derived neu...

Genetic and epigenetic changes contribute to deregulation of gene expression and development of human cancer. Changes in DNA methylation are key epigenetic factors regulating gene expression and genomic stability. Recent progress in microarray technologies resulted in developments of high resolution platforms for profiling of genetic, epigenetic and gene expression changes. OS is a pediatric bo...

introduction: respiratory pathogen, chlamydia pneumoniae, has been implicated in the pathogenesis of coronary artery disease. previous studies have demonstrated an antichlamydial seroresponse to be a cardiovascular risk factor and coronary atheromata to contain chlamyial components in varing proportions. endovascular demonstration of bacterial dna is required to provide evidence for an infectio...

Previously, we discovered that ZFP57 is a maternal-zygotic effect gene, and it maintains DNA methylation genomic imprint at multiple imprinted regions in mouse embryos. Despite these findings, it remains elusive how DNA methyltransferases are targeted to the imprinting control regions to initiate and maintain DNA methylation imprint. To gain insights into these essential processes in genomic im...

Genomes have both deterministic and random aspects, with the underlying DNA sequences exhibiting features at numerous scales, from codons and cis-elements through genes and on to regions of conserved or divergent gene order. The DNAWords program aims to identify mathematical structures that characterize genomes at multiple scales. The focus of this work is the fine structure of genomic sequence...