Background and Purpose—Different coagulation disorders have been associated with cerebral venous thrombosis (CVT). Until now, fewer than 50 patients have been reported with CVT and the factor V Leiden (FVL) mutation. Although the prevalence of FVL-positive patients with CVT ranged from 10% to 25%, it was as low as 0.5% to 3% in the control groups. Most other studies had not systematically searc...

BACKGROUND Many patients with asthma require frequent rescue medication for acute symptoms despite appropriate controller therapies. Thus, determining the most effective relief regimen is important in the management of more severe asthma. This study's objective was to evaluate whether ipratropium bromide/albuterol metered-dose inhaler (CVT-MDI) provides more effective acute relief of bronchospa...

BACKGROUND AND PURPOSE Different coagulation disorders have been associated with cerebral venous thrombosis (CVT). Until now, fewer than 50 patients have been reported with CVT and the factor V Leiden (FVL) mutation. Although the prevalence of FVL-positive patients with CVT ranged from 10% to 25%, it was as low as 0.5% to 3% in the control groups. Most other studies had not systematically searc...

Reducing the availability and uptake of fatty acids is a plausible pharmaceutical target to ameliorate glucose intolerance and insulin resistance. CVT-3619 [2-{6-[((1R,2R)-2-hydroxycyclopentyl) amino]purin-9-yl(4S,5S,2R,3R)-5-[(2-fluorophenylthio)methyl]oxolane-3,4-diol] is a partial A(1) adenosine receptor agonist with antilipolytic properties. Aims of the present study were to examine the acu...

among the causes of headache, cerebral venous and/or dural sinus thrombosis (cvt) is an important challenge because of its variable clinical presentation, having negative brain ct in up to 30% of cases and unavailability of mri in some situations. on the other hand as d-dimer (dd) test has been reported to be a sensitive test for the exclusion of venous thromboembolism, we sought whether it cou...

INTRODUCTION Patients with headache constitute up to 4.5% of emergency department (ED) visits. [1] Cerebral venous thrombosis (CVT) is an important cause of the headache that is more common than once suspected. The diagnosis of CVT is often missed or delayed because of nonspecific clinical manifestations, and brain computerized tomography (CT) may easily be misinterpreted. [2] Herein we report ...

Abstract Cerebral venous (sinus) thrombosis (CVT) is an unusual manifestation of causing severe neurological impairment and seizures 1,2 . Molecular mechanisms underlying CVT, potentially involving pathological platelet activation, are unknown. Here we show that antibody-(INU1-fab)-induced cooperative signaling two receptors, C-type lectin-like receptor-2 (CLEC-2) GPIIb/IIIa, triggers within mi...

The purpose of functional tolerancing process is to define the geometrical specifications of parts ensuring functional requirements. For automotive and aircraft industries, the tolerance synthesis has become an important issue in product design process. Indeed, designers need methods and rules to determine the tolerances. To define rules, a mathematical formulation of tolerance synthesis is det...