BACKGROUND The histologic grade of a prostate needle-core biopsy specimen can determine whether a patient with prostate cancer is a candidate for radical prostatectomy or other treatment. Incorrect histologic grading can result in inappropriate treatment and possible liability. Thus, we conducted this study to determine the histologic-grading accuracy of prostate cancer needle-core biopsy speci...

To evaluate the potential role of several clinical and pathological parameters in prediction of seminal vesicle invasion in patients with clinically localized prostate cancer undergoing radical prostatectomy. We retrospectively analyzed the medical records of patients who undergone radical prostatectomy from January 2005 until November 2010. Patients age, prostate volume, PSA, PSA density, perc...

Gleason grading is now the most widely used grading system for prostatic carcinoma in the United States. However, there are only a few studies of the interobserver reproducibility of this system, and no extensive study of interobserver reproducibility among a large number of experienced urologic pathologists exists. Forty-six needle biopsies containing prostatic carcinoma were assigned Gleason ...

Background. Protective factors against Gleason upgrading and its impact on outcomes after surgery warrant better definition. Patients and Methods. Consecutive 343 patients were categorized at biopsy (BGS) and prostatectomy (PGS) as Gleason score, ≤6, 7, and ≥8; 94 patients (27.4%) had PSA recurrence, mean followup 80.2 months (median 99). Independent predictors of Gleason upgrading (logistic re...

Endothelial cell-specific molecule 1 (ESM1) is a major prognostic marker of several tumor types, but its value as a marker for prostate cancer is unknown. The purpose of the present study was to measure the relationship of ESM1 expression with androgen receptor (AR) expression and with Gleason score in human prostate carcinoma tissue. Expression of ESM1 and AR were determined by immunohistochem...

PURPOSE To retrospectively assess the utility of whole-lesion apparent diffusion coefficient (ADC) metrics in characterizing the Gleason 4 component of Gleason 7 prostate cancer (PCa) at radical prostatectomy. MATERIALS AND METHODS Seventy patients underwent phased-array coil 3T-magnetic resonance imaging (MRI) before prostatectomy. A uropathologist mapped locations and Gleason 4 percentage (...

We prove a sharp inequality conjectured by Bobkov on the measure of dilations of Borel sets in the Euclidean space by a s-concave probability measure. Our result gives a common generalization of an inequality of Nazarov, Sodin and Volberg and a concentration inequality of Guédon. Applying our inequality to the level sets of functions satisfying a Remez type inequality, we deduce, as it is class...

Several maximal inequalities of Kahane-Khintchine’s type in certain Orlicz spaces are proved. The method relies upon Lévy’s inequality and the technique established in [14] which is obtained by Haagerup-Young-Stechkin’s best possible constants in the classical Khintchine inequalities. Moreover by using Donsker’s invariance principle it is shown that the numerical constant in the inequality dedu...

A 64-year-old man with a prostate-specific antigen (PSA) of 5·74 ng/mL, no lower urinary symptoms, and family history prostate cancer presented at our clinic University College London Hospital (London, UK) in April, 2018. Axial T2-weighted MRI the showed multicystic lesion (PSA density 0·07 ng/mL/mL), MRI-targeted biopsies Gleason 3 + adenocarcinoma (Gleason Grade Group 1) prostatic intraepithe...

The connections between binary and ternary error-correcting codes on the one hand, and lattices and sphere-packings in W on the other have been studied by several authors [6,7, 19-21,26,29,30,39,40-j. Since the theorem of Gleason, Pierce and Turyn [l, p. 381; 21 states that codes over GF(2), GF(3) and GF(4) have especially nice properties not shared by codes over other fields, one might expect ...