In Part 1 of this series, the subject of scrotal syphilis in the rabbit was considered from the standpoint of the local reaction to infection. The various elements in this reaction were noted, and the process was traced from the time of inoculation to the development of characteristic skin lesions. Especial attention was called to the multiform character of these reactions and the influence of ...

Among patients which develop glioblastoma multiform (GBM), recurrence is the rule despite continuous progress in surgery, radiotherapy and chemotherapy. In the adult, GBM is the most frequent and most aggressive tumour of the Central Nervous System. A better understanding of the mechanisms by which these tumours relapse could promote the use of preventive therapy and could increase patients' su...

The detailed description of the distribution of endocrine cells G and D producing important hormones that regulate activation of other cells in the human stomach may be a valuable source of information for opinions about mucosa changes in different diseases of the alimentary tract. The density and distribution of immunoreactive G and D cells in the pylorus of humans (donors of organs) were eval...

Orofacial granulomatosis is defined by permanent or recurrent swelling of orofacial tissues with different multiform and multifocal clinical patterns. An 11-year old boy presented with a 2-month history of mucosa enlargement. Intraoral examination revealed an erythematous, polylobulated, exophytic lesion with a smooth surface located in retromolar mucosa, non-tender and non-infiltratated to pal...

Brain gliomas are characterized by invasive growth and neovascularisation potential. Angiogenesis plays a major role in the progression of gliomas and its determination has a great prognostic value. The aim of the study was to assess the vascularisation of chosen brain gliomas and to estimate how it is correlated with tumour histological type, malignancy grade, location and size, and with age a...

Beta-blockers are a multiform group of drugs with multiple applications in the treatment of patients with cardiovascular disease. Their adverse actions are multiple and relate mainly to the β-adrenergic receptor blockade.They are used to treat all forms of coronary disease, but especially in acute myocardial infarction and acute coronary syndromes. The administration to patients with coronary a...

EphA4, an Ephrins tyrosine kinase receptor, behaves as a dependence receptor (DR) by triggering cell apoptosis in the absence of its ligand Ephrin-B3. DRs act as conditional tumor suppressors, engaging cell death based on ligand availability; this mechanism is bypassed by overexpression of DRs ligands in some aggressive cancers. The pair EphA4/Ephrin-B3 favors survival of neuronal progenitors o...

The malignancy of glioblastoma multiform (GBM), the most common and aggressive form of human brain tumors, strongly correlates with the presence of hypoxic areas, but the mechanisms controlling the hypoxia-induced aggressiveness are still unclear. GBM cells express a number of ion channels whose activity supports cell volume changes and increases in the cytosolic Ca(2+) concentration, ultimatel...

DETAILED descriptions of frequent and multiform variations of the vascular elements of the renal pedicle are to be found in the literature.1-9 The subject has recently been well reviewed by Merklin and Michaels.1'" Embryologic interpretations of such variations have been given by Broman,11 Jeidel,'2 Felix,'3 and Bremer.'4 It is the purpose of the present work to describe a type of aberrant rena...

During the past 12 years 7 examples have been encountered of brief arrhythmic episodes which we have called the "cardiac ballet". They consist of sequences of multiform ventricular (QRST) complexes, with or without ventricular complexes of the shape of sinus beats interspersed. The special feature of the arrhythmia is that the characteristic patterns of the sequences are from time to time repli...