A Lagrangian multiform structure is established for a generalisation of the Darboux system describing orthogonal curvilinear coordinate systems. It has been shown in past that this coupled PDEs fact an encoding entire Kadomtsev-Petviashvili (KP) hierarchy terms so-called Miwa variables. Thus, providing description multidimensionally consistent amounts to new 3-form continuous KP system. matrix ...

PURPOSE Molecular targeted therapy is an important approach for advanced hepatocellular carcinoma (HCC). Hepatitis B virus-related HCC (HBV-HCC) accounts for approximately 50% of all HCC cases. Bortezomib, a proteasome inhibitor (PI), is used extensively for the treatment of hematologic malignancies, but its application in HCC, particularly in HBV-HCC, has not been fully explored. EXPERIMENTA...

objective: to assess relative biological effectiveness (rbe) of 131i radiation relative to 60co gamma rays in glioblastoma spheroid cells. materials and methods: in this experimental study, glioblastoma spheroid cells were exposed to 131i radiation and 60co gamma rays. radiation induced dna damage was evaluated by alkaline comet assay. samples of spheroid cells were treated by radiation from 13...

giant cell glioblastoma is an extremely rare variant of glioblastoma (who grade iv) which is characterized by a predominance of bizarre, multinucleated giant cells. these tumors comprise of 0.8% of brain tumors and up to 5% of glioblastomas. in pediatric age group, these tumors are still uncommon with only around 53 published cases since 1952. here, we report a case of a 12-year old female pati...

background: combination therapy has generated remarkable motivation in the clinical setting since it boosts the therapeutic potential of anticancer drugs. glioblastoma multiforme (gbm) is the most common and aggressive malignant brain tumor which affects patients in all ages, and being principally resistant to treatment. methods: in this study, temozolomide as a standard chemotherapeutic drug f...

The event-related potential (ERP) effect of mismatch negativity (MMN) was the first electrophysiological probe to evaluate cognitive processing (change detection) in newborn infants. Initial studies of MMN predicted clinical utility for this measure in identification of infants at risk for developmental cognitive deficits. These predictions have not been realized. We hypothesized that in sleepi...

MOTIVATION High-throughput data is providing a comprehensive view of the molecular changes in cancer tissues. New technologies allow for the simultaneous genome-wide assay of the state of genome copy number variation, gene expression, DNA methylation and epigenetics of tumor samples and cancer cell lines. Analyses of current data sets find that genetic alterations between patients can differ bu...

Investigators from different domains are frequently confronted with large volumes of data originating from multiple sources that need to be analyzed simultaneously. Inhomogeneities within datasets thereby often obstruct the analysis process, but can also be the source potentially interesting relationships in the data. Most existing visualization techniques do not take such inhomogeneities into ...

The induction of ventricular tachycardia by ventricular stimulation was investigated in 46 patients with isolated Wolff-Parkinson-White syndrome (10 concealed) and 36 control patients with normal electrocardiograms and conduction systems. None of those studied had spontaneous ventricular arrhythmias or myocardial or valve disease. Single and double ventricular extrastimuli were delivered at 3 c...

The interpretation of much/many has been argued to be regulated by Uniform Dimensionality (Hackl 2000; Solt 2009): much is underspecified but many encodes cardinality. However, given some data where denotes ‘volume’, Snyder (2021) proposes the need for Multiform Dimensionality: both and are underspecifed. After reviewing English data, in light novel cross-linguistic we argue that neither genera...