This paper discusses fundamentals of hybrid system modelling. Emphazis is put on compositionality and the use of multiform time. Compositionality refers to the ability of freely composing hybrid systems. Since hybrid systems are considered, different time indices occur, and modularity calls for considering “time” as local to each module, this is what is called multiform time. The proposed frame...

Two patients known to have coronary artery disease died suddenly outdoors while active. Neither had symptoms or signs of acute myocardial infarction. They were being monitored by continuous tape recording of the electrocardiogram at the time of death. In one patient the cause of death was cardiac arrest, preceded by bigeminy and multiform ventricular ectopic beats, in the other ventricular fibr...

We present an introduction to the mathematical theory of the Lagrangian formalism for multiform fields on Minkowski spacetime based on the multiform and extensor calculus. Our formulation gives a unified mathematical description for the main relativistic field theories including the gravitational field (which however will be discussed in a separate paper). We worked out several examples (includ...

objective(s): our previous study showed that a newly designed tracer radioiodinated 6-(3-morpholinopropoxy)-7-ethoxy-4-(3'-iodophenoxy)quinazoline ([125i]pyk) is promising for the evaluation of the epidermal growth factor receptor (egfr) status and prediction of gefitinib treatment of non-small cell lung cancer. egfr is over-expressed and mutated also in glioblastoma. in the present study,...

Multiform glioblastoma is the most common primary, highly invasive, malignant tumor of the central nervous system, with an extremely poor prognosis. The median survival of patients following surgical resection, radiation therapy and chemotherapy does not exceed 12-15 months and thus, novel approaches for the treatment of the disease are required. The phenomenon of the directed migration of stem...

Glioblastoma multiform (GBM) is one of the most lethal human malignant brain tumors with high risks of recurrence and poor treatment outcomes. The RNA-binding protein Musashi-1 (MSI1) is a marker of neural stem/progenitor cells. Recent study showed that high expression level of MSI1 positively correlates with advanced grade of GBM, where MSI1 increases the growth of GBM. Herein, we explore the ...

Glioblastoma multiform (GBM) is one of the most lethal forms of brain cancers. The biggest difficulties for diagnostics and treatment of GBM underlie in its dynamic and complex macro and microenvironment. Glioma cells, stromal cells and tumor-associated immune cells (microglia/macrophage-TAMs) become a complex tissue with physical and chemical communication network. TAMs are the predominant inf...

Chemokines are biologically active peptides involved in the pathogenesis of various pathologies including brain malignancies. They are amongst primitive regulators of the development of immune responses against malignant glial tumors. The present study aimed to examine the expression of CC chemokines in anaplastic astrocytoma and glioblastoma multiform patients at both mRNA and protein levels. ...

Studying early response to cancer treatment is significant for patient treatment stratification and follow-up. Although recent advances in positron emission tomography (PET) and magnetic resonance imaging (MRI) allow for evaluation of tumor response, a quantitative objective assessment of treatment-related effects offers localization and quantification of structural and functional changes in th...

BACKGROUND Radiomics can quantify tumor phenotypic characteristics non-invasively by applying feature algorithms to medical imaging data. In this study of lung cancer patients, we investigated the association between radiomic features and the tumor histologic subtypes (adenocarcinoma and squamous cell carcinoma). Furthermore, in order to predict histologic subtypes, we employed machine-learning...