Type I glycogen storage diseases (GSD-I) consist of two major autosomal recessive disorders, GSD-Ia, caused by a reduction glucose-6-phosphatase-α (G6Pase-α or G6PC) activity and GSD-Ib, in the glucose-6-phosphate transporter (G6PT SLC37A4) activity. The G6Pase-α G6PT are functionally co-dependent. Together, G6Pase-α/G6PT complex catalyzes translocation G6P from cytoplasm into endoplasmic retic...

The need for a new vertical datum in Canada dates back to 1976 when a study group at the Geodetic Survey Division (GSD) of Natural Resources Canada investigated problems related to the existing vertical reference system (CGVD28) and recommended a redefinition of the vertical datum. The US National Geodetic Survey and GSD cooperated in the development of a new North American Vertical Datum (NAVD...

PURPOSE OF REVIEW Glycogen storage disorders (GSDs) are inborn errors of metabolism with abnormal storage or utilization of glycogen. The present review focuses on recent advances in hepatic GSD types I, III and VI/IX, with emphasis on clinical aspects and treatment. RECENT FINDINGS Evidence accumulates that poor metabolic control is a risk factor for the development of long-term complication...

The analysis of the combined results from three independent industry focused case studies, undertaken in the area of distributed software development over a period of eight years, has resulted in the identification of ten key factors. These ten factors have been utilised as the basis for the development of the GSD Implementation Model. The objective of the creation and presentation of this mode...

in september 2015, the international community came together to agree on the 2030 agenda for sustainable development, a plan of action for people, the planet, and prosperity. ambitious and far-reaching as they are, they are built on three keystones: the elimination of extreme poverty, fighting climate change, and a commitment to fighting injustice and inequality. critical to the achievement of ...