MOTIVATION Gene class testing (GCT) is a statistical approach to determine whether some functionally predefined classes of genes express differently under two experimental conditions. GCT computes the P-value of each gene class based on the null distribution and the gene classes are ranked for importance in accordance with their P-values. Currently, two null hypotheses have been considered: the...

The dedifferentiated giant-cell tumor of the bone is a very rare variant of the giant-cell tumor (GCT). We report the clinical, radiographic and histological findings of a dedifferentiated GCT in which the dedifferentiated component consisted of small round cells. We also comment on previously reported cases of dedifferentiated GCT, discuss the clinical implications of this dual histology, and ...

Giant cell tumor (GCT) is a benign bone tumor with aggressive characteristics. They are more prevalent in the third decade of life and demonstrate a preference for locating in the epiphyseal region of long bones. They have a high local recurrence rate, which depends on the type of treatment and initial tumor presentation. The risk of lung metastases is around 3%. Between October 2010 and August...

Cryptorchidism is the most well-defined risk factor for the development of testicular GCT; if uncorrected, the relative risk is 5 to 9 times that of healthy age-matched controls.[1] Approximately 10% of all cases of testicular GCT are associated with cryptorchidism and 10% of patients with cryptorchidism develop testicular GCT.[2,3] When testicular GCT develops in patients with unilateral crypt...

ally involves the metaphysis and epiphysis of long bones. Although the spine is the fourth leading location of GCT, most of these lesions occur in the sacrum, followed by the thoracic, cervical and lumbar vertebrae (1). GCT of bone is a benign, but potentially aggressive lesion that shows local recurrence and metastases. Metastatic lung disease rarely originates from a benign tumor, but this ca...

background hypovitaminosis d has been associated with the development of gestational diabetes mellitus (gdm) in many observational studies. objectives we report the first study of the impact of prenatal vitamin d supplementation on postpartum dysglycemia in gdm patients in a randomized clinical trial. patients and methods women with gdm at 12 - 32 weeks of gestation were assigned randomly to ei...

A 4-month-old infant presented with asymptomatic soft nodules on his right forearm, which had developed since birth. On the suspicion of nevus lipomatosus superficialis (NLS), biopsy was performed. Histopathologic findings showed monomorphic polygonal cells with abundant granular cytoplasm. Immunohistochemical stains for CD68 and vimentin were strongly positive, but were negative for S-100 prot...

Pulmonary granular cells tumors (CGT) are rare tumors, that derive from Schwann cells. In the tracheobronchial and pulmonary tree, they remain a diagnostic challenge. There no well-established criteria to differentiate between benign, atypical, malignant GCT. Moreover, its real frequency in respiratory tract is still unknown. Here, we represent 2 cases of bronchial lung GCTs. We aim highlight a...

Granular cell tumor (GCT) is a rare neoplasm that develops in the gut's submucosal layer. We report the case of a male with a history of surgically excised colon neoplasm where a rectal polyp was identified during a follow-up endoscopy. The lesion, eventually identified as a GCT, was endoscopically removed by band ligation-assisted mucosectomy. This may be the second report of a colorectal GCT ...