nifedipine (nif), a 1,4-dihydropyridine calcium channel antagonist, undergoes photo-degradation to dehydro-nifedipine (dnif) upon exposure to ultraviolet (uv) light and to the nitroso analogue of dehydro-nifedipine (ndnif) when exposed to sunlight or some kinds of artificial lights. nif photo-degradation products do not contribute to clinical activity, thus prevention of photo-degradation of ni...

Analytical methods were developed for the identification of major degradation products of Ketoconazole, an antifungal agent. The stressed degradation of Ketoconazole drug substance was performed under acid, base, thermal, photo and oxidative stress conditions. The major degradation was observed under acid, base and oxidative stress conditions. The degradation study was performed on Inertsil ODS...

An increase in low molecular weight fibrin-fibrinogen degradation products (FDP) was demonstrated in cerebrospinal fluid (CSF) from 17 of 18 patients with bacterial or viral meningitis compared with 29 patients without meningitis. The CSF also showed an increase in coagulation proteins of molecular weight less than 90000 (factors VII, IX, and plasminogen) but did not contain fibrinogen (MW 3400...

As part of a large-scale study of menstrual blood loss in the community serum fibrin degradation products were measured soon after menstruation in 331 women. No significant correlation was found between the amount of blood lost and the serum level of fibrin degradation products. These findings conflict with reports suggesting that excessive intrauterine fibrinolysis, which may play a part in me...

Imine or Schiff base formation is considered as a key event in the catalytic mechanisms of many enzymes and certain biological transformations, including glycation. In this process, less stable amino-acid-derived bases rearrange into more ketoamines Amadori products. are also stipulated to be stabilized through complexation with metal ions, intramolecular cyclization form reversible cyclic isom...

The non-enzymatic browning of glucose was investigated by accelerating the glucose degradation with or without heating glucose solutions for 1 h at 100°C with different reagents. Evaluation of the glucose degradation was performed using two types of glucose, glucose A and glucose B, in order to investigate the influence of the glucose manufacturing process on glucose discoloration. The color fo...

The most important challenge in peritoneal dialysis (PD) is long-term preservation of peritoneal membrane structure and function. Introduction of dialysis fluids into the peritoneal cavity induces changes. These changes are related to duration of dialysis, occurrence of peritonitis and components of the dialysis solution. Bioincompatibility is considered to be the major cause of the development...

On account of its minimal expense and a high potential for change into energy-producing products, lignocellulosic biomass is the future bioenergy energy. Notwithstanding, their true capacity restricted by utilization inefficient unstable enzymes. Therefore, present work aim to investigate cellulose degradation two isolated fungal species Aspergillus terreus Trichoderma harzanium followed bioeth...

The presence of fibrin in the joints, raised levels of blood fibrinogen, and an increased total daily fibrinogen turnover are well-known features of rheumatoid arthritis (Takeda, 1967) and inflammatory arthritis. A possible role for fibrin in the pathogenesis of rheumatoid arthritis, through its action as an autoimmunogen, was suggested by the production of a chronic inflammatory arthritis in r...

Two rapid, simple, sensitive, selective and economic derivative spectrophotometric (first [D1] and second [D2]) and synchronous spectrofluorimetric (FDSFS and SDSFS) methods have been developed for the analysis of fexofenadine hydrochloride (FXD) in the presence of its different degradation products. Derivative spectrophotometry (D1) was used to measure FXD at 223 nm in the presence of its alka...