BACKGROUND AND OBJECTIVE Iron is an essential element that is necessary for all cells in the body. Iron deficiency anemia (IDA) is one of the most common nutritional disorders in both developed and developing countries. The glutathione pathway is paramount to antioxidant defense and glucose-6-phosphate dehydrogenase (G6PD)-deficient cells do not cope well with oxidative damage. The goal of this...

in this study, 285 cases of congenital adrenal hyperplasia who were followed in the tehran university hospitals and institute of endocrinology and metabolism arc reported. among these cases, 165 (57.9%) were female and 120 (42.1%), male. the most common type of congenital adrenal hyperplasia in these patients was the salt-losing type of 21-hydroxylase deficiency (57.9%); 11-hydroxylase deficien...

The overall incidence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Iranian population is estimated around 10%-14.9%. G6PD deficiency is an X-linked disorder and 80% of donors are usually male. At present, donors’ blood is not routinely screened for G6PD deficiency in Iran blood bank where for detecting such enzyme deficiency, reliance is placed on pre-donation data. Thus, the G6PD ...

A deficiency in human erythrocyte glucose 6-phosphate dehydrogenase may be genetically determined (l-4) or occur in normal erythrocytes as they age in tivo (5, 6). The inherited glucose-6-P dehydrogenase deficiency, which is associated with hemolytic anemia upon exposure to a variety of agents, affords an opportunity in man to study further the mechanisms by which genes can lead to a decrease i...

background: one of the most important enzymatic disorders that interact with malaria is deficiency of g6pd (gloucose-6-phosphate dehydrogenase). this enzyme protects red blood cells from hydrogen peroxide and other oxidative damages. distribution of this enzyme deficiency usually accompanies with low level distribution of malaria disease in most malarious areas. so this hypothesis may be consid...

Carney-Stratakis Syndrome (CSS), first described in 2002 [1], encompasses Gastrointestinal Stromal Tumors (GISTs) and Paragangliomas (PGLs) has autosomal dominant inheritance with incomplete penetrance [2]. Germline mutations of Succinate Dehydrogenase (SDH) complex subunits consequent SDH functional deficiency have been identified as responsible for CSS [3]. Here, we present a case new mutatio...