نتایج جستجو برای: glycogen synthase kinase 3 beta
تعداد نتایج: 2182353 فیلتر نتایج به سال:
GSK3beta and Cdk5 are the two kinases in the center of research on Alzheimer's disease (AD), involved in the pathological symptoms of AD, Abeta plaque formation, tau hyperphosphorylation and neurodegeneration. So far, both kinases have mostly been examined in isolation, leading to a schism of the research field into defenders of the GSK3beta-versus the Cdk5 hypotheses of AD. However, in this de...
Activity-dependent modifications in synapse structure play a key role in synaptic development and plasticity, but the signaling mechanisms involved are poorly understood. We demonstrate that glutamatergic Drosophila neuromuscular junctions undergo rapid changes in synaptic structure and function in response to patterned stimulation. These changes, which depend on transcription and translation, ...
Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/Akt/mTORC, Ras/Raf/MEK/ERK, hedgehog (Hh), Notch and TP53 pathways elicit essential regulatory influences on cancer initiation, EMT and progression. A common kinase involved in all these pathways is moon-lighting kinase glycogen synthase...
Glycogen synthase kinase 3 (GSK3) is a vital multifunctional molecule that widely distributed in invertebrates and vertebrates. GSK3 highly conserved serine/threonine (Ser/Thr) protein kinase, which plays an important role insulin, Wnt, various signaling pathways. In this study, gene were identified the genome of Pacific white shrimp, Litopenaeus vannamei , analyzed its structure, phylogeny, ex...
Exposure of human alveolar macrophages to bacterial LPS results in activation of a number of signal transduction pathways. An early event after the alveolar macrophage comes in contact with LPS is activation of the phosphatidylinositol 3 kinase (PI 3-kinase). This study evaluates the downstream effects of that activation. We observed that LPS exposure results in phosphorylation of Akt (serine 4...
Mitochondrial trafficking deficits have been implicated in the pathogenesis of several neurological diseases, including Alzheimer's disease (AD). The Ser/Thre kinase GSK3β is believed to play a fundamental role in AD pathogenesis. Given that GSK3β substrates include Tau protein, here we studied the impact of GSK3β on mitochondrial trafficking and its dependence on Tau protein. Overexpression of...
The exposure of humans to fluorine is connected with its presence in the air, food and water. It well known that fluorides even at a low concentration but long time accumulate body lead numerous metabolic disorders. Fluoride recognised as factor modulating energy metabolism cells. This interaction particular importance muscle cells, which are cells high activity related glucose glycogen. In som...
In the course of structure-activity relationship studies we were interested in the synthesis of isoindigo and 7'-azaisoindigo derivatives substituted at the N-1 position by a 1-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl), at the 5'-position by various chains introduced by Sonogashira cross-coupling and substituted or not at the 5-position by a bromine atom. To get an insight into the substit...
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