in this study a 3-factor, 3-level box-behnken design was used to prepare optimized docetaxel (dtx) loaded pegylated poly lactide-co-glycolide (peg-plga) nps with polymer concentration (x1), drug concentration (x2) and ratio of the organic to aqueous solvent (x3) as the independent variables and particle size (y1), poly dispersity index (pdi) (y2) and drug loading (y3) as the responses. the cyto...

The treatment of large-area bone defects remains a challenge; however, various strategies have been developed to improve the performances of scaffolds in bone tissue engineering. In this study, poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) scaffold was coated with Asp-Gly-Glu-Ala (DGEA)-incorporated collagen for the repair of rat skull defect. Our results indicated that the mechanical str...

In this study, we investigated the effects of temozolomide (TMZ)/Poly (lactide-co-glycolide)(PLGA)/nano-hydroxyapatite microspheres on the behavior of U87 glioma cells. The microspheres were fabricated by the "Solid/Water/Oil" method, and they were characterized by using X-Ray diffraction, scanning electron microscopy and differential scanning calorimetry. The proliferation, apoptosis and invas...

Using poly(lactide-co-glycolide) (PLGA) particles for drug encapsulation and delivery has recently gained considerable popularity for a number of reasons. An advantage in one sense, but a drawback of PLGA use in another, is that drug delivery systems made of this material can provide a wide range of dissolution profiles, due to their internal structure and properties related to particles' manuf...

Polymeric microparticles have been used widely for sustained drug delivery. Current methods of microparticle production can be improved by making homogeneous particles in size and shape, increasing the drug loading, and controlling the initial burst release. In the current study, the hydrogel template method was used to produce homogeneous poly(lactide-co-glycolide) (PLGA) microparticles and to...

Background: The innovative repair materials for the bones are still lacking. So, we synthesized a porous microsphere by using basic fibroblast growth factor (bFGF), polylactide-co-glycolide (PLGA), poly L-lactic acid (PLLA) and hydroxylapatite (HAP), and its biocompatibility with bone marrow mesenchymal stem cells (BM-MSCs) was investigated in vitro. Methods: A modified solvent extraction/evapo...

Visceral leishmaniasis (VL) persists as a major public health problem, and since the existing chemotherapy is far from satisfactory, development of an effective vaccine emerges as the most appropriate strategy for confronting VL. The development of an effective vaccine relies on the selection of the appropriate antigen and also the right adjuvant and/or delivery vehicle. In the present study, t...

Poly(lactide-co-glycolide) (PLGA) has been widely used for scaffolding materials in tissue engineering. It degrades mainly via hydrolysis of the ester bonds into lactic acid and glycolic acid leading to the decrease in pH of the surrounding microenvironment. The current study was designed to quickly neutralize the acidic degradation products of PLGA fibrous scaffolds by incorporating tripolypho...

Microspheres formulated from poly (D, L-lactic-co-glycolide) (PLGA), a biodegradable polymer, have been extensively evaluated as a drug delivery system. In this study, the preparation, characterization and drug release properties of the PLGA microspheres were evaluated. Simvastatin (SIM)-loaded PLGA microspheres were prepared by oil-in-water emulsion/solvent evaporation method. The microspheres...

The aim of this study was to fabricate camptothecin/iron(III) oxide (CPT/Fe₂O₃)-loaded poly(D,L-lactide-co-glycolide) (PLGA) composite mats to modulate the CPT release and to improve the structural integrity and antitumor activity of the released drug. The CPT/Fe₂O₃-loaded PLGA ultrafine fibers were prepared for the first time by electrospinning a composite solution of CPT/Fe₂O₃ and neat PLGA (...