We developed the photo-crosslinkable hydrogel microfluidic co-culture device to study photothermal therapy and cancer cell migration. To culture MCF7 human breast carcinoma cells and metastatic U87MG human glioblastoma in the microfluidic device, we used 10 w/v% gelatin methacrylate (GelMA) hydrogels as a semi-permeable physical barrier. We demonstrated the effect of gold nanorod on phototherma...

Gold-gold sulfide nanoparticles are of interest for drug delivery, biomedical imaging, and photothermal therapy applications due to a facile synthesis method resulting in small particles with high near-infrared (NIR) absorption efficiency. Previous studies suggest that the NIR sensitivity of these nanoparticles was due to hexagonally shaped metal-coated dielectric nanoparticles that consist of ...

A dendrimer porphyrin (DP)-coated gold nanoshell (AuNS-DP) was prepared for the synergistic combination of photodyanmic and photothermal therapy. The resultant AuNS-DP successfully exhibited the generation of reactive oxygen species (ROS) as well as photothermal effect for the simultaneous application of photodynamic therapy (PDT) and photothermal therapy (PTT).

Bcl-2-associated athanogene 1 (Bag-1) is a positive regulator of Bcl-2 which is an anti-apoptotic gene. Bag-1 was very slightly expressed in normal tissues, but often highly expressed in many tumor tissues, particularly in colon cancer, which can promote metastasis, poor prognosis and anti-apoptotic function of colon cancer. We prepared and evaluated magnetic gold nanoparticle/Bag-1 siRNA recom...

The optical response of heterogeneous plasmonic trimer structures composed of a silver nanoparticle dimer and a central gold nanoparticle is investigated analytically and numerically. The plasmon resonance of the silver dimer is controlled through near-field coupling, resulting in plasmon resonance frequency matching of the silver dimer and gold monomer. This coupling condition makes it possibl...