Four male cousins showed clinical and biochemical features of X-linked recessive congenital adrenocortical hypoplasia. In addition, they showed varying degrees of androgenic precocity. One was virilised at birth. Another showed advanced growth and skeletal maturation. The remaining two had genital measurements greater than normal for age and showed raised testosterone levels, although pituitary...

A case of successful pregnancy in an in-vitro fertilization cycle, in spite of an accidental exposure to daily long-acting gonadotrophin-releasing hormone analogue administration, is reported. The patient underwent two intracytoplasmic sperm injection cycles with thawed epididymal spermatozoa, in which, due to a pharmacist's mistake, ovarian stimulation was carried out by a combination of long-...

Ovarian folliculogenesis is a dynamic process characterized by a marked proliferation and differentiation of the somatic cell components of the follicle. The developing follicle provides the optimal environment for the maturation of the oocyte in readiness for its subsequent fertilization after ovulation. The primary regulators of folliculogenesis are the gonadotrophins, which regulate ovarian ...