Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a central role in immune regulation and inflammation. Its importance in moderating both innate and adaptive immune responses is evidenced by the broad array of cells that secrete this cytokine, including monocytes, macrophages, T cells, and B cells. IL-6 directs chemokine-regulated trafficking of leukocytes and induces proliferation and ...

This letter explores the effect of the directivity of a source on time reversal acoustic focusing of energy. A single loudspeaker produces an airborne focus of sound in a reverberation chamber and in a classroom. Individual foci are created at microphone positions that surround the loudspeaker. The primary axis of the loudspeaker is then rotated and experiments are repeated to average out the r...

The successful treatment of certain autoimmune conditions with the humanized anti-IL-6 receptor (IL-6R) antibody tocilizumab has emphasized the clinical importance of cytokines that signal through the β-receptor subunit glycoprotein 130 (gp130). In this Review, we explore how gp130 signaling controls disease progression and examine why IL-6 has a special role among these cytokines as an inflamm...

The biological abilities of interleukin?6 (IL?6) have been under investigation for nearly 40 years. IL?6 works through an interaction with the complex peptide receptor (IL?6R). is built four ??chain nanostructures, while two different chains, IL?6R? (gp80) and gp130/IL6? (gp130), are included in IL?6R. three?dimensional shapes six chains composing IL?6/IL?6R basis nanomolecular roles signalling...

Interleukin-11 (IL-11) is a pleiotropic cytokine with both pro- and anti-inflammatory properties. It activates its target cells via binding to the membrane-bound IL-11 receptor (IL-11R), which then recruits homodimer of ubiquitously expressed, signal-transducing gp130. Besides this classic signaling pathway, can also bind soluble forms IL-11R (sIL-11R), IL-11/sIL-11R complexes activate inductio...

BACKGROUND & AIMS Trefoil factors (TFFs) regulate mucosal repair and suppress tumor formation in the stomach. Tff1 deficiency results in gastric cancer, whereas Tff2 deficiency increases gastric inflammation. TFF2 expression is frequently lost in gastric neoplasms, but the nature of the silencing mechanism and associated impact on tumorigenesis have not been determined. METHODS We investigate...

Stimulation of the interleukin-6 (IL-6) signalling pathway occurs via the IL-6 receptor-glycoprotein 130 (IL-6R-gp130) receptor complex and results in the regulation of acute-phase protein genes in liver cells. Ligand binding to the receptor complex leads to tyrosine phosphorylation and activation of Janus kinases (Jak), phosphorylation of the signal transducing subunit gp130, followed by recru...

We describe a novel cytokine receptor named GP130 Like receptor, or GPL, that displays similarities with the interleukin-6 and interleukin-12 family of signaling receptors. Four different isoforms diverging in their carboxyl terminus were isolated, corresponding to proteins encompassing 560, 610, 626, and 745 amino acids. Sequences included a signal peptide of 32 amino acids, followed by a cyto...

gp130, a signal-transducing receptor component of interleukin 6 (IL-6), associates with an IL-6 and IL-6 receptor (IL-6) complex and transduces signals. To examine the role of gp130 signaling in the expansion of human hemopoietic progenitor cells, we tested the effects of a recombinant soluble human IL-6 receptor (sIL-6R) and/or IL-6 in combination with other cytokines on purified human umbilic...

OBJECTIVES To assess the potential of the donor heart to respond to interleukin-6 (IL6), the present study investigated the expression of IL6 receptor components in the myocardium of donor hearts before transplantation. BACKGROUND Donor heart dysfunction early after transplantation has been associated with the cytokine storm after donor brain death. Proinflammatory cytokines are thought to pl...