Dipeptidyl peptidase 4 (DPP-4; also known as CD26), a transmembrane receptor expressed on T cells, has costimulatory function in activating cells. In mouse model, down-regulation of CD26 prevented graft-versus-host disease (GVHD) but preserved graft-versus-tumor effects. Whether inhibition DPP-4 with sitagliptin may prevent acute GVHD after allogeneic stem-cell transplantation is not known.

background: coronary artery bypass graft (cabg) surgery is very traumatic and makes patients very nervous. since it is a main task of nurses to improve patients' comfort and safety, this study investigated the effect of therapeutic touch in cardiovascular patients' anxiety before cabg surgery. methods: in a controlled clinical trail study the simple random sampling was used to select 44 patient...

purpose: to compare the clinical outcomes following deep anterior lamellar keratoplasty (dalk) for keratoconic patients with vernal keratoconjunctivitis (vkc) and without vkc. methods: in this retrospective comparative study, the records for 262 eyes with keratoconus only (group 1) and 28 keratoconic eyes with vkc (group 2) that underwent dalk were complied. the parameters reviewed included the...

acute respiratory distress syndrome (ards) is a potential complication of cardiac surgery, given that patients undergoing cabg frequently have hypoxemia and pulmonary dysfunction during initial hours after surgery. thus, ards criteria in these patients are more likely to be positive while these criteria may not match the patient`s clinical picture. we aimed to investigate frequency of rapid ons...

this study evaluates the effect of preoperative increased level of serum creatinine (cr) on early outcomes after coronary artery bypass graft surgery (cabg). 1140 patients who underwent cabg in our center were studied. patients with cr >2.25 mg/dl or preoperative dialysis and who had off-pump operations were excluded. group 1 consisted of 892 patients with normal cr (0.5-1.2 mg/dl) and group 2 ...

conclusions the type and amount of fluid replacement therapy and optimizing hemodynamic status, before and during reperfusion of the transplanted kidney, are of particular importance during renal transplantation surgery. results general anesthesia was performed in 82% of patients and for the rest of them, spinal, epidural and combined spinal and epidural were done. the age of the patients was i...

introduction: as off pump coronary artery bypass grafting surgery (cabg) is a developing method in coronary cardiac surgery, most surgeons are anxious about the danger of emergency crash conversion. in this observational study we tried to show the rate and outcome of conversion . material and methods: in this descriptive study about 477 coronary off-pump cabg patients were operated in ghaem hos...

background we present a novel method for augmenting the standard c-v flap used for nipple reconstruction with a free dermal graft which aims to improve the appearance of the nipple reconstruction, decrease loss of projection and improve patient satisfaction overall. methods the surgical technique for performing a free dermal graft augmentation of a cv flap is described. all patients who underwe...

background the ala of the nose, with its particular texture and characteristics, poses both aesthetically and functionally intriguing challenges and is rather problematic regarding choices for reconstructive methods. both flaps and grafts have been used to restore natural structure of nasal ala. the present study summarizes a ten-year experience of reconstructive surgery using small composite g...