The sugar nucleotide dTDP-L-rhamnose is critical for the biosynthesis of the Group A Carbohydrate, the molecular signature and virulence determinant of the human pathogen Group A Streptococcus (GAS). The final step of the four-step dTDP-L-rhamnose biosynthesis pathway is catalyzed by dTDP-4-dehydrorhamnose reductases (RmlD). RmlD from the Gram-negative bacterium Salmonella is the only structura...

Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA), which are found in the cell walls of gram-negative and gram-positive bacteria, respectively. This study was conducted to determine if TLRs are present on chicken heterophils and if these receptors mediate oxidative burst. Heterophils isolated from neo...

Introduction: Neonatal sepsis is one of the major contributors mortality and morbidity among neonates. Irrational overuse antibiotics have led to an increase in antimicrobial resistance. This study was undertaken investigate bacteriological profile, resistance predictors blood culture-positive cases neonatal sepsis. Methods: Demographic data were collected from electronic manual case records. A...

The Tigecycline Evaluation and Surveillance Trial (T.E.S.T.) was initiated in 2004 to longitudinally monitor the activity of the broad-spectrum glycylcycline antimicrobial tigecycline, and a suite of comparator agents, against an array of clinically important bacterial pathogens worldwide. In this report, we examine the activity of tigecycline and comparators against a collection of 13,245 clin...

The mammalian innate immune system recognizes pathogen-associated molecular patterns through pathogen recognition receptors. Nod1 has been described recently as a cytosolic receptor that detects specifically diaminopimelate-containing muropeptides from Gram-negative bacteria peptidoglycan. In the present study we investigated the potential role of Nod1 in the innate immune response against the ...

background and objectives: anaerobic bacteria are recognized as important pathogens in surgical infections. however, they are the most overlooked microorganisms by the clinic and the laboratory because of the tedious culture techniques with longer turn-around times. the study was aimed to analyze the frequency of anaerobic bacterial surgical infections and their predisposing factors. materials ...

background and aims. bacterial contamination of dental unit water supplies (duws) has attracted a lot of attention in recent years due to the emergence of serious infections in susceptible dental patients. the aim of the present study was to evaluate the presence of gram-negative bacterial contamination in duws at tabriz university of medical sciences faculty of dentistry. materials and methods...