Nonsteroidal antiinflammatory drugs like ibuprofen impede tissue repair by virtue of retarding inflammation. The present study was undertaken to explore if linking of nitrooxyethyl ester to ibuprofen reverses its healing-depressant propensity. Nitrooxyethyl ester of ibuprofen (NOE-Ibu) was synthesized in our laboratory through a well-established synthetic pathway. NOE-Ibu was screened for its i...

Leaf extract of guava (Psidium guajava Linn.) has been reported to promote wound healing in traditional medicine but there is paucity of information in literature regarding similar activity of fruit extract. Therefore, the present study was planned to investigate the influence of leaf and fruit extract of Psidium guajava Linn. on re-sutured incision, excision, and dead space wounds in male Wist...

Negative pressure wound therapy (NPWT) with reticulated open-cell foam (ROCF) dressings (ROCF G, V.A.C.® GranuFoamTM Dress- ing, KCI USA, Inc, San Antonio, TX) creates a healing environment that removes wound exudates, reduces edema, and promotes perfusion and granulation tissue formation. Controlled instillation of saline dur- ing NPWT (NPWTi) may further enhance healing by facilitating auto- ...

Granulation tissue fibroblasts (myofibroblasts) develop several ultrastructural and biochemical features of smooth muscle (SM) cells, including the presence of microfilament bundles and the expression of alpha-SM actin, the actin isoform typical of vascular SM cells. Myofibroblasts have been proposed to play a role in wound contraction and in retractile phenomena observed during fibrotic diseas...

INDIAN PEDIATRICS 1094 VOLUME 43__DECEMBER 17, 2006 An 8-year-old boy diagnosed as Glanzmann thrombasthenia (GT) by other center was referred to our department in March 2005. He has been followed with GT for 4 years. He complained difficulty in breathing and recurrent upper respiratory tract infections. We observed a big perforation at nasal septum and granulation tissue related with forgotten ...

A 64-year-old woman presented to clinic with 2 months of episodic chest tightness at rest, which would last several minutes before spontaneous resolution. Her pertinent medical history included tobacco abuse, hypertension, and hypothyroidism. In addition, she had resection of a left atrial myxoma in the year 2000, after she presented with similar chest discomfort. That procedure involved resect...