The crystal structure of [d(CGCAAATTTGCG)]2 has been determined to 1.5 A resolution, representing the first high-resolution structure of this DNA fragment. The ion interactions are novel. A spermine molecule replaces a Mg2+ observed in analogous structures. Unlike lower-resolution structures, the minor groove is narrow and the major groove lacks extra Watson-Crick hydrogen bonds. In addition, a...

We theoretically study channel plasmon-polaritons (CPPs) with a geometry similar to that in recent experiments at telecom wavelengths (Bozhevolnyi et al., Nature 440, 508 (2006)). The CPP modal shape, dispersion relation, and losses are simulated using the multiple multipole method and the finite difference time domain technique. It is shown that, with the increase of the wavelength, the fundam...

This paper describes the GROOVE solution to the “Class Diagram Restructuring” case study of the Tool Transformation Contest 2013 [4]. GROOVE [5, 2] is designed to support state space exploration and model checking of dynamically evolving systems; however, as we will show in this contribution, it can also be used to demonstrate graph transformations as a basis for model transformation. GROOVE’s ...

In this letter, we demonstrate the possibility of an effective nano-scale FabryPerot interferometer in a sub-wavelength plasmonic waveguide in the form of a triangular groove on a metal surface, guiding channel plasmon-polaritons (CPPs). The resonant cavity is formed by two semitransparent metal membranes (mirrors) placed into the groove. Effective filtering effect of the cavity is demonstrated...

REASONS FOR PERFORMING STUDY To improve understanding of the internal structure of the proximal phalanx (P1), response of the bone to load and possible relation to the pathogenesis of fractures in P1. OBJECTIVES To model the P1 and replicate the loads experienced by the bone in stance, walk, trot and gallop using finite element analysis. METHODS The geometry of the P1 was captured using mic...

BACKGROUND It has been extensively developed in recent years that cell-permeable small molecules, such as polyamide, can be programmed to disrupt transcription factor-DNA interfaces and can silence aberrant gene expression. For example, cyclic pyrrole-imidazole polyamide that competes with glucocorticoid receptor (GR) for binding to glucocorticoid response elements could be expected to affect t...

BACKGROUND This study evaluates changes in peri-articular bone in two canine models for osteoarthritis: the groove model and the anterior cruciate ligament transection (ACLT) model. METHODS Evaluation was performed at 10 and 20 weeks post-surgery and in addition a 3-weeks time point was studied for the groove model. Cartilage was analysed, and architecture of the subchondral plate and trabecu...

Duplication of the left anterior descending (LAD) coronary artery is a rare anomaly (incidence 1%) characterized by a short LAD that terminates high in the anterior interventricular groove and a long LAD that has a proximal course outside the anterior interventricular groove and returns to the groove in its distal course. The Type 4 variant of this anomaly is extremely rare whereby a long LAD a...

The drum machine has been an important tool in music production for decades. However, its flawless way of playing drum patterns is often perceived as mechanical and rigid, far from the groove provided by a human drummer. This paper presents research towards enhancing the drum machine with learning capabilities. The drum machine learns user-specific variations (i.e. the groove) from human drumme...

With aging, anatomical changes are observed in the face. In the lower third, these changes are expressed as ptosis of the angle of the mouth, lip enhancement groove mentalis; decrease in concavity between the jaw and neck and very noticeable platysmal banding. The repeated contraction of muscles of the lateral-chin together with the band platysmal side form what are called a marionette groove. ...