Submit Manuscript | http://medcraveonline.com Abbreviations: R/M: Recurrent and/or Metastatic; HNSSC: Head and Neck Squamous Cell Carcinoma; FU: Fluorouracil; PFS: Progression-Free Survival; OS: Overall Survival; EGFR: Epidermal Growth Factor Receptor; TGF-α: Transforming Growth Factor-Alpha; TKI: Tyrosine Kinase Inhibitors; mAb: Monoclonal Antibodies; ACU: Area Under the Concentration; PD 1: P...

The association between rapamycin and astrocytes in a tumor-bearing mouse model with brain metastases of non-small cell lung cancer (NSCLC) was investigated. For in vitro experiments, NCI-H358, a human lung adenocarcinoma cell line, was co-cultured with immortalized astrocytes, and treated with rapamycin, an mTOR inhibitor. We evaluated the expression of interleukin-1 (IL-1), interleukin-3 (IL-...

Submit Manuscript | http://medcraveonline.com Abbreviations: R/M: Recurrent and/or Metastatic; HNSSC: Head and Neck Squamous Cell Carcinoma; FU: Fluorouracil; PFS: Progression-Free Survival; OS: Overall Survival; EGFR: Epidermal Growth Factor Receptor; TGF-α: Transforming Growth Factor-Alpha; TKI: Tyrosine Kinase Inhibitors; mAb: Monoclonal Antibodies; ACU: Area Under the Concentration; PD 1: P...

results cloning was confirmed by pcr and restriction digestion. rt-pcr and sds-page represented expression of kgf in e. coli. the optimized expression was achieved 16 hours after induction with 0.3 mm iptg at 37°c in luria broth (lb) containing kanamycin. the 18 kda protein was confirmed by western blotting, using anti-his antibodies. conclusions the result of the present study indicated that e...

results our results revealed that the serum levels of tgf-β were significantly increased in chb patients in compare to healthy controls. conclusions according to this result, it may be concluded that high serum levels of tgf-β may be a mechanism by which immune response against hbv is suppressed. background the transforming growth factor-β (tgf-β) is an important cytokine with anti-inflammatory...

BACKGROUND/PURPOSE The liver has a remarkable capacity to regenerate after injury or resection. The aim of this review is to outline the mechanisms and factors affecting liver regeneration after liver transplantation. METHODS Relevant studies were reviewed using Medline, PubMed and Springer databases. RESULTS A variety of cytokines (such as interleukin-6 and tumor necrosis factor-α), growth...

Background:  New discoveries about the pathophysiology changed the concept that all forms of osteoarthritis are alike; this lead to the delineation of different phenotypes such as age, trauma or obese related forms. We aim to compare soluble mediator profiles in primary knee and posttraumatic wrist osteoarthritis. Based on the general faster progression rate of wrist osteoarthritis, we hypothes...

To test the significance of lipid peroxidation in the development of alcoholic liver injury, an ethanol (EtOH) liquid diet was fed to male 129/SvJ mice (wild-type, WT) and glutathione S-transferase A4-4-null (GSTA4-/-) mice for 40 days. GSTA4-/- mice were crossed with peroxisome proliferator-activated receptor-α-null mice (PPAR-α-/-), and the effects of EtOH in the resulting double knockout (dK...