OBJECTIVE Use of growth hormone is associated with side effects, including insulin resistance. The objective of this study was to determine whether tesamorelin, a stabilized growth hormone-releasing hormone analogue, would alter insulin sensitivity or control of diabetes. DESIGN A 12-week randomized, placebo-controlled study of 53 patients with type 2 diabetes. Three treatment groups: placebo...

The first step in insulin action consists in binding of the hormone to specific cell surface receptors. This receptor displays two functional domains: an extracellular alpha-subunit containing the majority or the totality of the hormone binding site and an intracellular beta-subunit possessing insulin-stimulated tyrosine kinase activity. A general consensus has been reached in favour of the ide...

Background Endometrial cancer is a hormone-dependent disease and has been consistently associated with obesity. Non genetic lifestyle factors may account for more than 75% of endometrial cancer cases and represent potential targets for prevention of this disease. Insulin resistance induced by diet may play a particularly pernicious role in the development of endometrial cancer, possibly by redu...

conclusions the inhibition of mini-puberty period in male rats was demonstrated to have an effect on their testicular function to some extent. results serum t and lh levels peaked at two hours after birth, while fsh peaked at hour 0, and bilateral testicular weight peaked at four hours after birth. the rats that underwent ether inhalation five minutes after birth had markedly reduced serum horm...

Growth hormone (GH) is secreted in a pulsatile pattern to promote body growth and metabolism. GH exerts its function by activating several signaling pathways, including JAK2/STAT and MEK/ERK. ERK1/2 activation by GH plays important roles in gene expression, cell proliferation, and growth. We previously reported that in rat H4IIE hepatoma cells after an initial GH exposure, a second GH exposure ...