BACKGROUND Investigate alterations in the expression and localization of carbohydrate units in rat retinal cells exposed to cisplatin toxicity. AIMS The aim of the study was to evaluate putative protective effects of selenium on retinal cells subjected to cisplatin. STUDY DESIGN Animal experiment. METHODS Eighteen healthy Wistar rats were divided into three equal groups: 1. Control, 2. Ci...

Changes in glycosphingolipid (GSL) composition during differ entiation of human leukemic granulocytes were investigated qualitatively and quantitatively in immature and mature granulocytic cells derived from human chronic myelogenous leukemia (CML) cases and were compared with those found in the in vitro granulocytic differentiation of the human promyelocytic leukemia HL-60 cell line. Two neutr...

(Env)-mediated cross-linking of their cell surface reDimiter S. Dimitrov* Laboratory of Experimental and Computational ceptors. Cholesterol depletion by methyl-b-cyclodextrin, which Biology NCI-FCRDC presumably disrupts rafts, inhibits HIV-1 infection and syncytia formation (J. Hildreth, Johns Hopkins Univ., National Institutes of Health Building 469, Room 104 Baltimore, R. Blumenthal). A limit...

Aksak ritimler, çağdaş çok sesli Türk müziği bestecileri tarafından da kullanılan müziğinin en karakteristik özelliklerinden birisidir. Birçok besteci aksak ritimleri, yazdıkları eserleriyle repertuvara kazandırmışlardır. Bu çalışmada Türkiye’deki Güzel Sanatlar Lisesi (GSL) için piyano eğitiminde kullanılmak üzere başlangıç düzeyi ritimli etüt ve alıştırmalar yazılmış öğretmenlerinin görüşleri...

Recently, Barrow holographic dark energy (BHDE), based on entropy, has been proposed to describe the late acceleration of universe. Contrary earlier analysis this model in literature, we consider BHDE with Granda-Oliveros length as IR cut-off, a dynamical vacuum, having constant equation state $\omega_{\Lambda}=-1.$ We have analytically solved for Hubble parameter and studied evolution cosmolog...

In the accompanying paper [Mellor, Neville, Harvey, Platt, Dwek and Butters (2004) Biochem. J. 381, 861-866] we treated HL60 cells with N-alk(en)yl-deoxynojirimycin (DNJ) compounds to inhibit glucosphingolipid (GSL) biosynthesis and identified a number of non-GSL-derived, small, free oligosaccharides (FOS) most likely produced due to inhibition of the oligosaccharide-processing enzymes a-glucos...

Membrane lipids play a pivotal role in the pathogenesis of Alzheimer's disease, which is associated with conformational changes, oligomerization and/or aggregation of Alzheimer's beta-amyloid (Abeta) peptides. Yet conflicting data have been reported on the respective effect of cholesterol and glycosphingolipids (GSLs) on the supramolecular assembly of Abeta peptides. The aim of the present stud...

Understanding plant metabolism as an integrated system is essential for metabolic engineering aimed at the effective production of compounds useful to human life and the global environment. The "omics" approach integrates transcriptome and metabolome data into a single data set and can lead to the identification of unknown genes and their regulatory networks involved in metabolic pathways of in...

Sea-level rise due to both climate change and non-climatic factors threatens coastal settlements, infrastructure and ecosystems. Projections of mean global sea level (GSL) rise provide insufficient information to plan adaptive responses; local decisions require local projections that accommodate different risk tolerances and time frames and that can be linked to storm surge projections. Here we...

The interaction of amyloid β-proteins (Aβ) with membrane gangliosides has been reported to be an early event in Aβ fibril formation in Alzheimer's disease (AD). Neuronal degeneration in AD has been postulated to be associated with the presence of anti-ganglioside antibodies in patient sera. Using an enzyme-linked immunosorbent assay (ELISA) and high-performance thin-layer chromatography (HPTLC)...