Netrins are bifunctional guidance molecules, attracting some axons and repelling others. They act through receptors of the DCC and UNC5 families. DCC receptors have been implicated in both attraction and repulsion by Netrins. UNC5 receptors are required only for repulsion. In Drosophila, Netrins are expressed by midline cells of the CNS and by specific muscles in the periphery. They attract com...

Netrin is a key axon guidance cue that orients axon growth during neural circuit formation. However, the mechanisms regulating netrin and its receptors in the extracellular milieu are largely unknown. Here we demonstrate that in Caenorhabditis elegans, LON-2/glypican, a heparan sulfate proteoglycan, modulates UNC-6/netrin signaling and may do this through interactions with the UNC-40/DCC recept...

Introduction: Consultation and guidance is a process of learning which is donethrough the relationship between two individuals. In this mutual relationship,the counselor, through his scientific and occupational skills and qualification,tries to help the students using the methods corresponding to their needs. Themain objective of this study was to provide a framework for the managementof the ad...

Blindfolded participants were guided along routes from two display modes: spatial language ("left," "right," or "straight") or spatialized audio (where the perceived sound location indicates the target direction). Half of the route guidance trials were run concurrently with a secondary vibrotactile N-back task. To assess cognitive map development, subjects performed a homing task from the route...

Primary motoneurons, the earliest developing spinal motoneurons in zebrafish, have highly stereotyped axon projections. Although much is known about the development of these neurons, the molecular cues guiding their axons have not been identified. In a screen designed to reveal mutations affecting motor axons, we isolated two mutations in the stumpy gene that dramatically affect pathfinding by ...

Previous genetic studies of intersegmental nerve b development have identified several cell-surface proteins required for correct axon guidance to appropriate target muscles. Here we provide evidence that the small GTPase Drac1 also plays a key role in this guidance process. Neuronal expression of the dominant negative mutation Drac1(N17) causes axons to bypass and extend beyond normal synaptic...